Cytokine Production by Peripheral Blood CD4+ and CD8+ T Cells in Atopic Childhood Asthma
Joint Authors
Mazur, Bogdan
Barć-Czarnecka, Malgorzata
Machura, Edyta
Rusek-Zychma, Malgorzata
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
There are conflicting studies on T cell cytokine production in childhood asthma.
In this study intracellular cytokine expression of IL-2, IL-4, IL-10, IL-13, IFN-γ, and TNF-α in CD4+ and CD8+ T cells in children with atopic asthma were measured by flow cytometry.
Results.
A significant increase in the percentage of CD4+ and CD8+ T cells producing IL-4 and IL-13 and decrease in the percentage of CD4+ producing IFN-γ in asthmatic children was found.
The percentage of CD4+/IL-13+ was significantly higher in severe asthma than in children with intermittent disease symptoms.
Severity of asthma was associated with increased both serum IgE and frequencies of CD4+/IL-13+ T cells, as well as duration of disease.
Moreover, a decrease in FEV1, FEV1/FVC was observed in relation to the severity of asthma.
Changes in cytokine profile in CD8+ subpopulation didn't depend on the severity of the disease.
Conclusions.
Increased production of IL-4 and IL-13 in both CD4+ and CD8+ T cells accompanied by decreased IFN-γ expression in CD4+ T cells may be evidence that both lymphocyte subpopulations are implicated in the pathogenesis of asthma.
Relationship of CD4+/IL-13+ T cells with disease activity suggests that this lymphocyte subset may have a prominent role in childhood asthma.
American Psychological Association (APA)
Machura, Edyta& Mazur, Bogdan& Rusek-Zychma, Malgorzata& Barć-Czarnecka, Malgorzata. 2010. Cytokine Production by Peripheral Blood CD4+ and CD8+ T Cells in Atopic Childhood Asthma. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989325
Modern Language Association (MLA)
Machura, Edyta…[et al.]. Cytokine Production by Peripheral Blood CD4+ and CD8+ T Cells in Atopic Childhood Asthma. Journal of Immunology Research No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-989325
American Medical Association (AMA)
Machura, Edyta& Mazur, Bogdan& Rusek-Zychma, Malgorzata& Barć-Czarnecka, Malgorzata. Cytokine Production by Peripheral Blood CD4+ and CD8+ T Cells in Atopic Childhood Asthma. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989325