Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages
Joint Authors
Bzowska, Małgorzata
Skalniak, Anna
Guzik, Krzysztof
Hamczyk, Magda
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Accumulation of neutrophils in the site of inflammation is a typical mechanism of innate immunity.
The accumulated neutrophils are exposed to stressogenic factors usually associated with inflammation.
Here, we studied response of human peripheral blood neutrophils subjected to short, febrile-range heat stress.
We show that 90 min heat stress slowed down the spontaneous apoptosis of neutrophils.
In the absence of typical markers of apoptosis the heat-shocked neutrophils induced antiinflammatory effect in human monocyte-derived macrophages (hMDMs), yet without being engulfed.
Importantly, the expression of FcγRIII (CD16) was sharply reduced.
Surprisingly, concentration of the soluble CD16 did not change in heat-shocked neutrophil supernates indicating that the reduction of the cell surface CD16 was achieved mainly by inhibition of fresh CD16 delivery.
Inhibitors of 90 kDa heat shock protein (HSP90), a molecular chaperone found in membrane platforms together with CD16 and CD11b, significantly increased the observed effects caused by heat shock.
The presented data suggest a novel systemic aspect of increased temperature which relies on immediate modification by heat of a neutrophil molecular pattern.
This effect precedes cell death and may be beneficial in the initial phase of inflammation providing a nonphlogistic signal to macrophages before it comes from apoptotic cells.
American Psychological Association (APA)
Bzowska, Małgorzata& Hamczyk, Magda& Skalniak, Anna& Guzik, Krzysztof. 2011. Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages. BioMed Research International،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-989980
Modern Language Association (MLA)
Bzowska, Małgorzata…[et al.]. Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages. BioMed Research International No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-989980
American Medical Association (AMA)
Bzowska, Małgorzata& Hamczyk, Magda& Skalniak, Anna& Guzik, Krzysztof. Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-989980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989980