Guillain-Barré Syndrome Animal Model: The First Proof of Molecular Mimicry in Human Autoimmune Disorder
Joint Authors
Yuki, Nobuhiro
Shahrizaila, Nortina
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Molecular mimicry between self and microbial components has been proposed as the pathogenic mechanism of autoimmune diseases, and this hypothesis is proven in Guillain-Barré syndrome.
Guillain-Barré syndrome, the most frequent cause of acute neuromuscular paralysis, sometimes occurs after Campylobacter jejuni enteritis.
Gangliosides are predominantly cell-surface glycolipids highly expressed in nervous tissue, whilst lipo-oligosaccharides are major components of the Gram-negative bacterium C.
jejuni outer membrane.
IgG autoantibodies to GM1 ganglioside were found in the sera from patients with Guillain-Barré syndrome.
Molecular mimicry was demonstrated between GM1 and lipo-oligosaccharide of C.
jejuni isolated from the patients.
Disease models by sensitization of rabbits with GM1 and C.
jejuni lipo-oligosaccharide were established.
Guillain-Barré syndrome provided the first verification that an autoimmune disease is triggered by molecular mimicry.
Its disease models are helpful to further understand the molecular pathogenesis as well as to develop new treatments in Guillain-Barré syndrome.
American Psychological Association (APA)
Shahrizaila, Nortina& Yuki, Nobuhiro. 2010. Guillain-Barré Syndrome Animal Model: The First Proof of Molecular Mimicry in Human Autoimmune Disorder. BioMed Research International،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990316
Modern Language Association (MLA)
Shahrizaila, Nortina& Yuki, Nobuhiro. Guillain-Barré Syndrome Animal Model: The First Proof of Molecular Mimicry in Human Autoimmune Disorder. BioMed Research International No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-990316
American Medical Association (AMA)
Shahrizaila, Nortina& Yuki, Nobuhiro. Guillain-Barré Syndrome Animal Model: The First Proof of Molecular Mimicry in Human Autoimmune Disorder. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990316