Therapeutic Implications of Mesenchymal Stem Cells in Liver Injury
Joint Authors
Gasbarrini, Giovanni Battista
Puglisi, Maria Ausiliatrice
Piscaglia, Anna Chiara
Tesori, Valentina
D'Ugo, Domenico M.
Gasbarrini, Antonio
Lattanzi, Wanda
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mesenchymal stem cells (MSCs), represent an attractive tool for the establishment of a successful stem-cell-based therapy of liver diseases.
A number of different mechanisms contribute to the therapeutic effects exerted by MSCs, since these cells can differentiate into functional hepatic cells and can also produce a series of growth factors and cytokines able to suppress inflammatory responses, reduce hepatocyte apoptosis, regress liver fibrosis, and enhance hepatocyte functionality.
To date, the infusion of MSCs or MSC-conditioned medium has shown encouraging results in the treatment of fulminant hepatic failure and in end-stage liver disease in experimental settings.
However, some issues under debate hamper the use of MSCs in clinical trials.
This paper summarizes the biological relevance of MSCs and the potential benefits and risks that can result from translating the MSC research to the treatment of liver diseases.
American Psychological Association (APA)
Puglisi, Maria Ausiliatrice& Tesori, Valentina& Lattanzi, Wanda& Piscaglia, Anna Chiara& Gasbarrini, Giovanni Battista& D'Ugo, Domenico M.…[et al.]. 2011. Therapeutic Implications of Mesenchymal Stem Cells in Liver Injury. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990351
Modern Language Association (MLA)
Puglisi, Maria Ausiliatrice…[et al.]. Therapeutic Implications of Mesenchymal Stem Cells in Liver Injury. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990351
American Medical Association (AMA)
Puglisi, Maria Ausiliatrice& Tesori, Valentina& Lattanzi, Wanda& Piscaglia, Anna Chiara& Gasbarrini, Giovanni Battista& D'Ugo, Domenico M.…[et al.]. Therapeutic Implications of Mesenchymal Stem Cells in Liver Injury. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990351