The Myocyte Expression of Adiponectin Receptors and PPARδ Is Highly Coordinated and Reflects Lipid Metabolism of the Human Donors
Joint Authors
Heni, Martin
Gommer, Nadja
Gasse, Lisa
Machicao, Fausto
Häring, Hans-Ulrich
Staiger, Harald
Haas, Carina
Ordelheide, Anna-Maria
Guirguis, Alke
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Muscle lipid oxidation is stimulated by peroxisome proliferator-activated receptor (PPAR) δ or adiponectin receptor signalling.
We studied human myocyte expression of the PPARδ and adiponectin receptor genes and their relationship to lipid parameters of the donors.
The mRNA levels of the three adiponectin receptors, AdipoR1, AdipoR2, and T-cadherin, were highly interrelated (r≥0.91).
However, they were not associated with GPBAR1, an unrelated membrane receptor.
In addition, the adiponectin receptors were positively associated with PPARδ expression (r≥0.75).
However, they were not associated with PPARα.
Using stepwise multiple linear regression analysis, PPARδ was a significant determinant of T-cadherin (P=.0002).
However, pharmacological PPARδ activation did not increase T-cadherin expression.
The myocyte expression levels of AdipoR1 and T-cadherin were inversely associated with the donors' fasting plasma triglycerides (P<.03).
In conclusion, myocyte expression of PPARδ and the adiponectin receptors are highly coordinated, and this might be of relevance for human lipid metabolism in vivo.
American Psychological Association (APA)
Ordelheide, Anna-Maria& Heni, Martin& Gommer, Nadja& Gasse, Lisa& Haas, Carina& Guirguis, Alke…[et al.]. 2011. The Myocyte Expression of Adiponectin Receptors and PPARδ Is Highly Coordinated and Reflects Lipid Metabolism of the Human Donors. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990678
Modern Language Association (MLA)
Ordelheide, Anna-Maria…[et al.]. The Myocyte Expression of Adiponectin Receptors and PPARδ Is Highly Coordinated and Reflects Lipid Metabolism of the Human Donors. Journal of Diabetes Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990678
American Medical Association (AMA)
Ordelheide, Anna-Maria& Heni, Martin& Gommer, Nadja& Gasse, Lisa& Haas, Carina& Guirguis, Alke…[et al.]. The Myocyte Expression of Adiponectin Receptors and PPARδ Is Highly Coordinated and Reflects Lipid Metabolism of the Human Donors. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990678