Serum Positive for the Autoantibody against the β1-Adrenoceptor from Chinese Patients with Congestive Heart Failure Decreases Iss in Mouse Cardiac Myocytes
Joint Authors
Ma, Zhi-Yong
Wang, Jian-chun
Li, Li
Zhang, Wei
Li, Xiao-Dong
Ma, Zhiyong
Wang, Yuan-yuan
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Autoantibodies targeting the β1-adrenergic receptor (AAB-β1) display agonist-like effects, which may have a pathogenic role in the progression of heart failure.
Here, we used the electrophysiological recordings to explore the effects of AAB-β1-positive serum from Chinese patients with heart failure on the activity of the peak transient outward potassium current (Ito) and the end 50 ms steady-state potassium current (Iss) in mouse cardiac myocytes.
We found that the AAB-β1-positive serum had no effect on the activity of Ito, but it produced a decrease in the currents of Iss.
A low concentration of positive serum (1/100) had a small inhibitory effect on Iss.
However, positive serum at 1 : 10, 1 : 20, and 1 : 50 significantly decreased Iss.
The concentration-dependence analysis showed that the EC50 of AAB-β1-positive serum was 1/60.24 and its nH was 2.86.
It indicated that the AAB-β1 could inhibit Iss in mouse cardiomyocyte in a concentration-dependent manner.
American Psychological Association (APA)
Wang, Yuan-yuan& Ma, Zhi-Yong& Li, Xiao-Dong& Wang, Jian-chun& Zhang, Wei& Li, Li…[et al.]. 2011. Serum Positive for the Autoantibody against the β1-Adrenoceptor from Chinese Patients with Congestive Heart Failure Decreases Iss in Mouse Cardiac Myocytes. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990726
Modern Language Association (MLA)
Wang, Yuan-yuan…[et al.]. Serum Positive for the Autoantibody against the β1-Adrenoceptor from Chinese Patients with Congestive Heart Failure Decreases Iss in Mouse Cardiac Myocytes. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-990726
American Medical Association (AMA)
Wang, Yuan-yuan& Ma, Zhi-Yong& Li, Xiao-Dong& Wang, Jian-chun& Zhang, Wei& Li, Li…[et al.]. Serum Positive for the Autoantibody against the β1-Adrenoceptor from Chinese Patients with Congestive Heart Failure Decreases Iss in Mouse Cardiac Myocytes. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990726