Effect of αB-Crystallin on Protein Aggregation in Drosophila
Joint Authors
Shimaji, Kouhei
Yamaguchi, Masamitsu
Tue, Nguyen Trong
Tanaka, Naoki
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Disorganisation and aggregation of proteins containing expanded polyglutamine (polyQ) repeats, or ectopic expression of α-synuclein, underlie neurodegenerative diseases including Alzheimer’s, Parkinson, Huntington, Creutzfeldt diseases.
Small heat-shock proteins, such as αB-crystallin, act as chaperones to prevent protein aggregation and play a key role in the prevention of such protein disorganisation diseases.
In this study, we have explored the potential for chaperone activity of αB-crystallin to suppress the formation of protein aggregates.
We tested the ability of αB-crystallin to suppress the aggregation of a polyQ protein and α-synuclein in Drosophila.
We found that αB-crystallin suppresses both the compound eye degeneration induced by polyQ and the α-synuclein-induced rough eye phenotype.
Furthermore, by using histochemical staining we have determined that αB-crystallin inhibits the aggregation of polyQ in vivo.
These data provide a clue for the development of therapeutics for neurodegenerative diseases.
American Psychological Association (APA)
Tue, Nguyen Trong& Shimaji, Kouhei& Tanaka, Naoki& Yamaguchi, Masamitsu. 2012. Effect of αB-Crystallin on Protein Aggregation in Drosophila. BioMed Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991517
Modern Language Association (MLA)
Tue, Nguyen Trong…[et al.]. Effect of αB-Crystallin on Protein Aggregation in Drosophila. BioMed Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-991517
American Medical Association (AMA)
Tue, Nguyen Trong& Shimaji, Kouhei& Tanaka, Naoki& Yamaguchi, Masamitsu. Effect of αB-Crystallin on Protein Aggregation in Drosophila. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991517