![](/images/graphics-bg.png)
Role of TGF-β1Smad3 Signaling Pathway in Secretion of Type I and III Collagen by Vascular Smooth Muscle Cells of Rats Undergoing Balloon Injury
Joint Authors
Lu, Ping
Sheng, Jing
Cai, Wenwei
Wang, Songhao
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Antisense Smad3 adenoviral vectors were used to transfect vascular smooth muscle cells (VSMCs) from rats with balloon injury or infused into the rat balloon-catheter injured carotid arteries, and the role of TGF-β1/Smad3 signaling pathway in the secretion of type I and III collagen by VSMCs following balloon injury was investigated.
Antisense Smad3 adenoviral vectors were used to transfect these VSMCs (antisense Smad3 group).
A total 90 rats were randomly assigned into blank control group, experiment group, negative control group.
In the in vitro study, the expression of type I and III collagen was markedly reduced in the antisense Smad3 group when compared with the control groups (P<0.05).
In the in vivo study, the expression of type I and III collagen was significantly lower than that in the negative control group at 3 days, 1 week and 2 weeks after injury (P<0.05).
At 2 weeks and 3 months after injury, the lumen area in the antisense Smad3 group was markedly increased but the intimal area dramatically reduced when compared with the negative control (P<0.05).
We conclude that transfection of VSMCs with antisense Smad3 can reduce the secretion of type I and III collagen which then inhibit intimal hyperplasia.
American Psychological Association (APA)
Lu, Ping& Wang, Songhao& Cai, Wenwei& Sheng, Jing. 2012. Role of TGF-β1Smad3 Signaling Pathway in Secretion of Type I and III Collagen by Vascular Smooth Muscle Cells of Rats Undergoing Balloon Injury. BioMed Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-991977
Modern Language Association (MLA)
Lu, Ping…[et al.]. Role of TGF-β1Smad3 Signaling Pathway in Secretion of Type I and III Collagen by Vascular Smooth Muscle Cells of Rats Undergoing Balloon Injury. BioMed Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-991977
American Medical Association (AMA)
Lu, Ping& Wang, Songhao& Cai, Wenwei& Sheng, Jing. Role of TGF-β1Smad3 Signaling Pathway in Secretion of Type I and III Collagen by Vascular Smooth Muscle Cells of Rats Undergoing Balloon Injury. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-991977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991977