Electroacupuncture Suppresses Discrete Cue-Evoked Heroin-Seeking and Fos Protein Expression in the Nucleus Accumbens Core in Rats
Joint Authors
Liu, Sheng
Zhu, Fenglei
Lai, Miaojun
Sun, Limin
Liu, Yijun
Zhou, Wenhua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Relapse to drug seeking was studied using a rodent model of reinstatement induced by exposure to drug-related cues.
Here, we used intravenous drug self-administration procedures in rats to further investigate the beneficial effects of electroacupuncture (EA) on heroin-seeking behavior in a reinstatement model of relapse.
We trained Sprague-Dawley rats to nose-poke for i.v.
heroin either daily for 4 h or 25 infusions for 14 consecutive days.
Then the rats were abstinent from heroin for two weeks.
2 Hz EA stimulation was conducted once daily for 14 days during heroin abstinence.
We tested these animals for contextual and discrete cue-induced reinstatement of active responses.
We also applied immunohistochemistry to detect Fos-positive nuclei in the nucleus accumbens (NACc) core and shell after reinstatement test.
We found that active responses elicited by both contextual cues and discrete cues were high in the rats trained with heroin than in saline controls.
EA treatment significantly reduced active responses elicited by discrete cues.
EA stimulation attenuated Fos expression in the core but not the shell of the NACc.
Altogether, these results highlight the therapeutic benefit of EA in preventing relapse to drug addiction.
American Psychological Association (APA)
Liu, Sheng& Zhu, Fenglei& Lai, Miaojun& Sun, Limin& Liu, Yijun& Zhou, Wenhua. 2012. Electroacupuncture Suppresses Discrete Cue-Evoked Heroin-Seeking and Fos Protein Expression in the Nucleus Accumbens Core in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992172
Modern Language Association (MLA)
Liu, Sheng…[et al.]. Electroacupuncture Suppresses Discrete Cue-Evoked Heroin-Seeking and Fos Protein Expression in the Nucleus Accumbens Core in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992172
American Medical Association (AMA)
Liu, Sheng& Zhu, Fenglei& Lai, Miaojun& Sun, Limin& Liu, Yijun& Zhou, Wenhua. Electroacupuncture Suppresses Discrete Cue-Evoked Heroin-Seeking and Fos Protein Expression in the Nucleus Accumbens Core in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992172