The Protective Effect of Apamin on LPSFat-Induced Atherosclerotic Mice
Joint Authors
Kim, Soo-Jung
Park, Ji-Hyun
Kim, Kyung-Hyun
Lee, Woo-Ram
Pak, Sok Cheon
Han, Sang-Mi
Park, Kwan-Kyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Apamin, a peptide component of bee venom (BV), has anti-inflammatory properties.
However, the molecular mechanisms by which apamin prevents atherosclerosis are not fully understood.
We examined the effect of apamin on atherosclerotic mice.
Atherosclerotic mice received intraperitoneal (ip) injections of lipopolysaccharide (LPS, 2 mg/kg) to induce atherosclerotic change and were fed an atherogenic diet for 12 weeks.
Apamin (0.05 mg/kg) was administered by ip injection.
LPS-induced THP-1-derived macrophage inflammation treated with apamin reduced expression of tumor necrosis factor (TNF)-α, vascular cell adhesion molecule (VCAM)-1, and intracellular cell adhesion molecule (ICAM)-1, as well as the nuclear factor kappa B (NF-κB) signaling pathway.
Apamin decreased the formation of atherosclerotic lesions as assessed by hematoxylin and elastic staining.
Treatment with apamin reduced lipids, Ca2+ levels, and TNF-α in the serum from atherosclerotic mice.
Further, apamin significantly attenuated expression of VCAM-1, ICAM-1, TGF-β1, and fibronectin in the descending aorta from atherosclerotic mice.
These results indicate that apamin plays an important role in monocyte/macrophage inflammatory processing and may be of potential value for preventing atherosclerosis.
American Psychological Association (APA)
Kim, Soo-Jung& Park, Ji-Hyun& Kim, Kyung-Hyun& Lee, Woo-Ram& Pak, Sok Cheon& Han, Sang-Mi…[et al.]. 2012. The Protective Effect of Apamin on LPSFat-Induced Atherosclerotic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992185
Modern Language Association (MLA)
Kim, Soo-Jung…[et al.]. The Protective Effect of Apamin on LPSFat-Induced Atherosclerotic Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992185
American Medical Association (AMA)
Kim, Soo-Jung& Park, Ji-Hyun& Kim, Kyung-Hyun& Lee, Woo-Ram& Pak, Sok Cheon& Han, Sang-Mi…[et al.]. The Protective Effect of Apamin on LPSFat-Induced Atherosclerotic Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992185