A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
Joint Authors
Zhang, Nan
Van Crombruggen, Koen
Holtappels, Gabriele
Bachert, Claus
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Patients seek an effective alternative to pharmacotherapy including herbal treatment options for allergic rhinitis and rhinosinusitis.
Material and Methods.
Nasal mucosal tissue was obtained from 12 patients, fragmented, preincubated with tissue culture medium, S.
baicalensis and/or E.
senticosus and/or vitamin C (each compound 0.2 μg/mL and 2 μg/mL) for 1 hour at 37°C/5% CO2, and stimulated with anti-IgE for 30 minutes and 6 hours to imitate the allergic early and late phases.
Furthermore, Staphylococcus aureus superantigen B (SEB) stimulation for 6 hours was used to imitate T-cell activation.
Results.
The combination of S.
baicalensis and E.
senticosus had a more potent suppressive effect on the release of PGD2, histamine, and IL-5 than S.
baicalensis alone.
The combination also resulted in a significant inhibition of SEB-induced cytokines comparable or superior to an established topical corticosteroid, fluticasone propionate.
Vitamin C increased ciliary beat frequency, but had no anti-inflammatory effects.
Discussion.
The combination of S.
baicalensis and E.
senticosus may be able to significantly block allergic early-and late-phase mediators and substantially suppress the release of proinflammatory, and Th1-, Th2-, and Th17—derived cytokines.
American Psychological Association (APA)
Zhang, Nan& Van Crombruggen, Koen& Holtappels, Gabriele& Bachert, Claus. 2012. A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992519
Modern Language Association (MLA)
Zhang, Nan…[et al.]. A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992519
American Medical Association (AMA)
Zhang, Nan& Van Crombruggen, Koen& Holtappels, Gabriele& Bachert, Claus. A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992519