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Before It Gets Started: Regulating Translation at the 5′ UTR
Joint Authors
Araujo, Patricia R.
Smith, Andrew D.
Ko, Daijin
Penalva, Luiz O. F.
Suresh, Uthra
Yoon, Kihoon
Qiao, Mei
Burns, Suzanne C.
Source
International Journal of Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Translation regulation plays important roles in both normal physiological conditions and diseases states.
This regulation requires cis-regulatory elements located mostly in 5′ and 3′ UTRs and trans-regulatory factors (e.g., RNA binding proteins (RBPs)) which recognize specific RNA features and interact with the translation machinery to modulate its activity.
In this paper, we discuss important aspects of 5′ UTR-mediated regulation by providing an overview of the characteristics and the function of the main elements present in this region, like uORF (upstream open reading frame), secondary structures, and RBPs binding motifs and different mechanisms of translation regulation and the impact they have on gene expression and human health when deregulated.
American Psychological Association (APA)
Araujo, Patricia R.& Yoon, Kihoon& Ko, Daijin& Smith, Andrew D.& Qiao, Mei& Suresh, Uthra…[et al.]. 2012. Before It Gets Started: Regulating Translation at the 5′ UTR. International Journal of Genomics،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992899
Modern Language Association (MLA)
Araujo, Patricia R.…[et al.]. Before It Gets Started: Regulating Translation at the 5′ UTR. International Journal of Genomics No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992899
American Medical Association (AMA)
Araujo, Patricia R.& Yoon, Kihoon& Ko, Daijin& Smith, Andrew D.& Qiao, Mei& Suresh, Uthra…[et al.]. Before It Gets Started: Regulating Translation at the 5′ UTR. International Journal of Genomics. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992899