Hyperglycemia Induces the Variations of 11β-Hydroxysteroid Dehydrogenase Type 1 and Peroxisome Proliferator-Activated Receptor-γ Expression in Hippocampus and Hypothalamus of Diabetic Rats
Joint Authors
Li, Guang
Qi, Wen-wen
Zhong, Li-yong
Liu, Zhao-xia
Chen, Nai-hong
Li, Xiao-rong
Hu, Jin-feng
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In this paper, we first observed that there were differences in expressions of 11β-HSD1 and PPAR-γ, in hippocampi and hypothalami, among constant hyperglycemia group, control group and the fluctuant glycemia group, using Immunohistochemical analysis.
However, whether in expression o f 11β-HSD1 or PPAR-γ, there were no statistic differences between the control group or the fluctuant glycemia group.
So, we removed the fluctuant glycemia group, retaining only constant hyperglycemia group and control group, being fed for 8 weeks.
After 8 weeks of induction, 11β-HSD1 expression increased and PPAR-γ expression decreased in the constant hyperglycemia group compared with control group, both in hippocampi and hypothalami, by Western Blot.
The constant hyperglycemia group also showed impaired cognition in MORRIS watermaze, lower serum corticosterone level, and higher Serum ACTH concentration after 8 weeks.
We inferred that the cognition impairment may be related to the abnormal expression of 11β-HSD1 and PPAR-γ in central nerves system.
As for 11β-HSD1 is a regulating enzyme, converting the inactive 11-dehydrocorticosterone into the active glucocorticoid corticosterone, thus amplifying GC action in local tissues.
It is also well known that high local GC levels can affect the cognitive function.
In addition, PPAR-a protective receptor, which is related to cognition.
American Psychological Association (APA)
Qi, Wen-wen& Zhong, Li-yong& Li, Xiao-rong& Li, Guang& Liu, Zhao-xia& Hu, Jin-feng…[et al.]. 2012. Hyperglycemia Induces the Variations of 11β-Hydroxysteroid Dehydrogenase Type 1 and Peroxisome Proliferator-Activated Receptor-γ Expression in Hippocampus and Hypothalamus of Diabetic Rats. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-993922
Modern Language Association (MLA)
Qi, Wen-wen…[et al.]. Hyperglycemia Induces the Variations of 11β-Hydroxysteroid Dehydrogenase Type 1 and Peroxisome Proliferator-Activated Receptor-γ Expression in Hippocampus and Hypothalamus of Diabetic Rats. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-993922
American Medical Association (AMA)
Qi, Wen-wen& Zhong, Li-yong& Li, Xiao-rong& Li, Guang& Liu, Zhao-xia& Hu, Jin-feng…[et al.]. Hyperglycemia Induces the Variations of 11β-Hydroxysteroid Dehydrogenase Type 1 and Peroxisome Proliferator-Activated Receptor-γ Expression in Hippocampus and Hypothalamus of Diabetic Rats. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-993922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-993922