Endoplasmic Reticulum Stress in the β-Cell Pathogenesis of Type 2 Diabetes
Joint Authors
Back, Sung Hoon
Kang, Sang-Wook
Han, Jaeseok
Chung, Hun Taeg
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Type 2 diabetes is a complex metabolic disorder characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency by β-cell failure.
Even if the mechanisms underlying the pathogenesis of β-cell failure are still under investigation, recent increasing genetic, experimental, and clinical evidence indicate that hyperactivation of the unfolded protein response (UPR) to counteract metabolic stresses is closely related to β-cell dysfunction and apoptosis.
Signaling pathways of the UPR are “a double-edged sword” that can promote adaptation or apoptosis depending on the nature of the ER stress condition.
In this paper, we summarized our current understanding of the mechanisms and components related to ER stress in the β-cell pathogenesis of type 2 diabetes.
American Psychological Association (APA)
Back, Sung Hoon& Kang, Sang-Wook& Han, Jaeseok& Chung, Hun Taeg. 2011. Endoplasmic Reticulum Stress in the β-Cell Pathogenesis of Type 2 Diabetes. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-994031
Modern Language Association (MLA)
Back, Sung Hoon…[et al.]. Endoplasmic Reticulum Stress in the β-Cell Pathogenesis of Type 2 Diabetes. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-994031
American Medical Association (AMA)
Back, Sung Hoon& Kang, Sang-Wook& Han, Jaeseok& Chung, Hun Taeg. Endoplasmic Reticulum Stress in the β-Cell Pathogenesis of Type 2 Diabetes. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-994031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994031