The Role of Metformin in the Management of NAFLD
Joint Authors
Fruci, Barbara
Belfiore, Antonino
Mazza, Angela
Malaguarnera, Roberta
Giuliano, Stefania
Garinis, Giorgia Anna
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide.
Its prevalence ranges 10–24% in the general population, reaching 60–95% and 28–55% in obese and diabetic patients, respectively.
Although the etiology of NAFLD is still unclear, several lines of evidences have indicated a pathogenetic role of insulin resistance in this disorder.
This concept has stimulated several clinical studies where antidiabetic drugs, such as insulin sensitizers including metformin, have been evaluated in insulin-resistant, NAFLD patients.
These studies indicate that metformin might be of benefit in the treatment of NAFLD, also in nondiabetic patients, when associated to hypocaloric diet and weight control.
However, the heterogeneity of these studies still prevents us from reaching firm conclusions about treatment guidelines.
Moreover, metformin could have beneficial tissue-specific effects in NAFLD patients irrespective of its effects as insulin sensitizer.
American Psychological Association (APA)
Mazza, Angela& Fruci, Barbara& Garinis, Giorgia Anna& Giuliano, Stefania& Malaguarnera, Roberta& Belfiore, Antonino. 2011. The Role of Metformin in the Management of NAFLD. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-994062
Modern Language Association (MLA)
Mazza, Angela…[et al.]. The Role of Metformin in the Management of NAFLD. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-994062
American Medical Association (AMA)
Mazza, Angela& Fruci, Barbara& Garinis, Giorgia Anna& Giuliano, Stefania& Malaguarnera, Roberta& Belfiore, Antonino. The Role of Metformin in the Management of NAFLD. Journal of Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-994062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994062