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Neurocognitive Impairment in HIV-Infected Naïve Patients with Advanced Disease: The Role of Virus and Intrathecal Immune Activation
Joint Authors
Airoldi, Monica
Tagliabue, Benedetta
Clerici, Mario
Annoni, Giorgio
Arosio, Beatrice
Bandera, Alessandra
Gori, Andrea
Rainone, Veronica
Trabattoni, Daria
Soria, Alessandro
Lapadula, Giuseppe
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
To investigate intrathecal immune activation parameters and HIV-RNA in HIV-associated neurocognitive disorders (HAND) of advanced naïve HIV-infected patients and to evaluate their dynamics before and after initiation of antiretroviral therapy (ART).
Methods.
Cross-sectional and longitudinal analysis of HIV RNA, proinflammatory cytokines (IL-6, IL-10, INF-γ, TNF-α, TGF-β1, and TGF-β2) and chemokines (MIP-1α, MIP-1β, and MCP-1) in plasma and cerebrospinal fluid (CSF) of HIV-infected patients with CD4 <200/μL.
Results.
HAND was diagnosed at baseline in 6/12 patients.
Baseline CSF HIV-RNA was comparable in patients with or without HAND, whereas CSF concentration of IL-6 and MIP-1β, proinflammatory cytokines, was increased in HAND patients.
CSF evaluation at 12 weeks was available in 10/12 cases.
ART greatly reduced HIV-RNA in all patients.
Nevertheless, IL-6 and MIP-1β remained elevated after 12 weeks of therapy in HAND patients, in whom CSF HIV RNA decay was slower than the plasmatic one as well.
Conclusion.
Immune activation, as indicated by inflammatory cytokines, but not higher levels of HIV-RNA is observed in advanced naïve HIV-infected patients with HAND.
In HAND patients, ART introduction resulted in a less rapid clearance of CSF viremia compared to plasma and no modifications of intratechal immune activation.
American Psychological Association (APA)
Airoldi, Monica& Bandera, Alessandra& Trabattoni, Daria& Tagliabue, Benedetta& Arosio, Beatrice& Soria, Alessandro…[et al.]. 2012. Neurocognitive Impairment in HIV-Infected Naïve Patients with Advanced Disease: The Role of Virus and Intrathecal Immune Activation. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994437
Modern Language Association (MLA)
Airoldi, Monica…[et al.]. Neurocognitive Impairment in HIV-Infected Naïve Patients with Advanced Disease: The Role of Virus and Intrathecal Immune Activation. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-994437
American Medical Association (AMA)
Airoldi, Monica& Bandera, Alessandra& Trabattoni, Daria& Tagliabue, Benedetta& Arosio, Beatrice& Soria, Alessandro…[et al.]. Neurocognitive Impairment in HIV-Infected Naïve Patients with Advanced Disease: The Role of Virus and Intrathecal Immune Activation. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994437