Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection

Joint Authors

Oh, Hyoung
Donohue, Clare
Morris, Devin
Guerra, Carlos
Khurasany, Melissa
Venketaraman, Vishwanath

Source

Journal of Immunology Research

Issue

Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-12-29

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology

Abstract EN

We examined the causes for decreased glutathione (GSH) in individuals with HIV infection.

We observed lower levels of intracellular GSH in macrophages from individuals with HIV compared to healthy subjects.

Further, the GSH composition found in macrophages from HIV+ subjects heavily favors oxidized glutathione (GSSG) which lacks antioxidant activity, over free GSH which is responsible for GSH’s antioxidant activity.

This decrease correlated with an increase in the growth of Mycobacterium tuberculosis (M.

tb) in macrophages from HIV+ individuals.

In addition, we observed increased levels of free radicals, interleukin-1 (IL-1), interleukin-17 (IL-17) and transforming growth factor-β (TGF-β) in plasma samples derived from HIV+ individuals compared to healthy subjects.

We observed decreased expression of the genes coding for enzymes responsible for de novo synthesis of GSH in macrophages derived from HIV+ subjects using quantitative PCR (qPCR).

Our results indicate that overproduction of proinflammatory cytokines in HIV+ individuals lead to increased production of free radicals.

This combined with the decreased expression of GSH synthesis enzymes leads to a depletion of free GSH and may lead in part to the loss of immune function observed in HIV patients.

American Psychological Association (APA)

Morris, Devin& Guerra, Carlos& Donohue, Clare& Oh, Hyoung& Khurasany, Melissa& Venketaraman, Vishwanath. 2011. Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-996805

Modern Language Association (MLA)

Morris, Devin…[et al.]. Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-996805

American Medical Association (AMA)

Morris, Devin& Guerra, Carlos& Donohue, Clare& Oh, Hyoung& Khurasany, Melissa& Venketaraman, Vishwanath. Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-996805

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-996805