PD-L1-Expressing Dendritic Cells Contribute to Viral Resistance during Acute HSV-1 Infection
Joint Authors
Carr, Daniel J. J.
Bryant-Hudson, Katie M.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The inhibitory receptor, Programmed Death 1 (PD-1), and its ligands (PD-L1/PD-L2) are thought to play a role in immune surveillance during chronic viral infection.
The contribution of the receptor/ligand pair during an acute infection is less understood.
To determine the role of PD-L1 and PD-L2 during acute ocular herpes simplex virus type 1 (HSV-1) infection, HSV-1-infected mice administered neutralizing antibody to PD-L1 or PD-L2 were assessed for viral burden and host cellular immune responses.
Virus titers were elevated in cornea and trigeminal ganglia (TG) of anti-PD-L1-treated mice which corresponded with a reduced number of CD80-expressing dendritic cells, PD-L1+ dendritic cells, and HSV-1-specific CD8+ T cells within the draining (mandibular) lymph node (MLN).
In contrast, anti-PD-L2 treatment had no effect on viral replication or changes in the MLN population.
Notably, analysis of CD11c-enriched MLN cells from anti-PD-L1-treated mice revealed impaired functional capabilities.
These studies indicate PD-L1-expressing dendritic cells are important for antiviral defense during acute HSV-1 infection.
American Psychological Association (APA)
Bryant-Hudson, Katie M.& Carr, Daniel J. J.. 2012. PD-L1-Expressing Dendritic Cells Contribute to Viral Resistance during Acute HSV-1 Infection. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996915
Modern Language Association (MLA)
Bryant-Hudson, Katie M.& Carr, Daniel J. J.. PD-L1-Expressing Dendritic Cells Contribute to Viral Resistance during Acute HSV-1 Infection. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-996915
American Medical Association (AMA)
Bryant-Hudson, Katie M.& Carr, Daniel J. J.. PD-L1-Expressing Dendritic Cells Contribute to Viral Resistance during Acute HSV-1 Infection. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996915