Macrophage-Mediated Inflammation and Disease: A Focus on the Lung
Joint Authors
Gwyer Findlay, Emily
Hussell, Tracy
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The lung is exposed to a vast array of inhaled antigens, particulate matter, and pollution.
Cells present in the airways must therefore be maintained in a generally suppressive phenotype so that excessive responses to nonserious irritants do not occur; these result in bystander damage to lung architecture, influx of immune cells to the airways, and consequent impairment of gas exchange.
To this end, the resident cells of the lung, which are predominantly macrophages, are kept in a dampened state.
However, on occasion the suppression fails and these macrophages overreact to antigenic challenge, resulting in release of inflammatory mediators, induction of death of lung epithelial cells, deposition of extracellular matrix, and development of immunopathology.
In this paper, we discuss the mechanisms behind this macrophage-mediated pathology, in the context of a number of inflammatory pulmonary disorders.
American Psychological Association (APA)
Gwyer Findlay, Emily& Hussell, Tracy. 2012. Macrophage-Mediated Inflammation and Disease: A Focus on the Lung. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-998825
Modern Language Association (MLA)
Gwyer Findlay, Emily& Hussell, Tracy. Macrophage-Mediated Inflammation and Disease: A Focus on the Lung. Mediators of Inflammation No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-998825
American Medical Association (AMA)
Gwyer Findlay, Emily& Hussell, Tracy. Macrophage-Mediated Inflammation and Disease: A Focus on the Lung. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-998825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998825