Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand
Joint Authors
Hayashi, Tomoko
Yao, Shiyin
Crain, Brian
Chan, Michael
Cottam, Howard B.
Lao, Fitzgerald
Carson, Dennis A.
Corr, Maripat
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Although the mechanisms for sustained chemokine gradients and recurring cell infiltration in sterile peritonitis have not been elucidated, toll-like receptors (TLRs) have been implicated.
To abate the deleterious recruitment of neutrophils in sterile inflammation, we repeatedly administered a TLR7 ligand that hyposensitized to TLR7 and receptors that converged on the MyD88-signaling intermediary and reduced cellular infiltration in murine autoimmune models of multiple sclerosis and arthritis.
To reduce potential adverse effects, a polyethylene glycol polymer was covalently attached to the parent compound (Tolerimod1).
The proinflammatory potency of Tolerimod1 was 10-fold less than the unconjugated TLR7 ligand, and Tolerimod1 reduced neutrophil recruitment in chemically induced peritonitis and colitis.
The effects of Tolerimod1 were mediated by the radioresistant cells in radiation chimeric mice and by mast cells in reconstituted mast cell-deficient mice (KitW-sh).
Although the Tolerimod1 had weak proinflammatory agonist activity, it effectively reduced neutrophil recruitment in sterile peritoneal inflammation.
American Psychological Association (APA)
Hayashi, Tomoko& Yao, Shiyin& Crain, Brian& Chan, Michael& Cottam, Howard B.& Lao, Fitzgerald…[et al.]. 2011. Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-998864
Modern Language Association (MLA)
Hayashi, Tomoko…[et al.]. Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand. Mediators of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-998864
American Medical Association (AMA)
Hayashi, Tomoko& Yao, Shiyin& Crain, Brian& Chan, Michael& Cottam, Howard B.& Lao, Fitzgerald…[et al.]. Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand. Mediators of Inflammation. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-998864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998864