Guilty Molecules, Guilty Minds? The Conflicting Roles of the Innate Immune Response to Traumatic Brain Injury
Joint Authors
Hellewell, Sarah Claire
Morganti-Kossmann, Maria Cristina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Traumatic brain injury (TBI) is a complex disease in the most complex organ of the body, whose victims endure lifelong debilitating physical, emotional, and psychosocial consequences.
Despite advances in clinical care, there is no effective neuroprotective therapy for TBI, with almost every compound showing promise experimentally having disappointing results in the clinic.
The complex and highly interrelated innate immune responses govern both the beneficial and deleterious molecular consequences of TBI and are present as an attractive therapeutic target.
This paper discusses the positive, negative, and often conflicting roles of the innate immune response to TBI in both an experimental and clinical settings and highlights recent advances in the search for therapeutic candidates for the treatment of TBI.
American Psychological Association (APA)
Hellewell, Sarah Claire& Morganti-Kossmann, Maria Cristina. 2012. Guilty Molecules, Guilty Minds? The Conflicting Roles of the Innate Immune Response to Traumatic Brain Injury. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-998881
Modern Language Association (MLA)
Hellewell, Sarah Claire& Morganti-Kossmann, Maria Cristina. Guilty Molecules, Guilty Minds? The Conflicting Roles of the Innate Immune Response to Traumatic Brain Injury. Mediators of Inflammation No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-998881
American Medical Association (AMA)
Hellewell, Sarah Claire& Morganti-Kossmann, Maria Cristina. Guilty Molecules, Guilty Minds? The Conflicting Roles of the Innate Immune Response to Traumatic Brain Injury. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-998881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998881