Apoptotic Cells Contribute to Melanoma Progression and This Effect is Partially Mediated by the Platelet-Activating Factor Receptor
المؤلفون المشاركون
Jancar, Sonia
Bachi, André Luis Lacerda
dos Santos, Lívia Caires
Nonogaki, Suely
Jasiulionis, Miriam Galvonas
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
There is evidence that the platelet-activating factor receptor (PAFR) is involved in the clearance of apoptotic cells by macrophages, and that this is associated with anti-inflammatory phenotype.
Our group has previously shown that coinjection of a large number of apoptotic cells can promote tumor growth from a subtumorigenic dose of melanoma cells.
Here, we studied the involvement of the PAFR in the tumor growth promoting effect of apoptotic cells.
A sub-tumorigenic dose of melanoma cells (Tm1) was coinjected with apoptotic Tm1 cells, subcutaneously in the flank of C57Bl/6 mice, and the volume was monitored for 30 days.
Animals received the PAFR antagonists, WEB2170 or PCA4248 (5 mg/kg body weight) or vehicle, by peritumoral daily injection for 5 days.
Results showed that PAFR antagonists significantly inhibited the tumor growth induced by the coinjection of a sub-tumorigenic dose of melanoma cells together with apoptotic cells.
This was accompanied by inhibition of early neutrophil and macrophage infiltration.
Addition of (platelet-activating factor) to this system has no significant effect.
PAFR antagonists did not affect the promoting effect of carrageenan.
We suggest that the recognition of apoptotic cells by phagocytes leads to activation of PAFR pathways, resulting in a microenvironment response favorable to melanoma growth.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bachi, André Luis Lacerda& dos Santos, Lívia Caires& Nonogaki, Suely& Jancar, Sonia& Jasiulionis, Miriam Galvonas. 2012. Apoptotic Cells Contribute to Melanoma Progression and This Effect is Partially Mediated by the Platelet-Activating Factor Receptor. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1001185
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bachi, André Luis Lacerda…[et al.]. Apoptotic Cells Contribute to Melanoma Progression and This Effect is Partially Mediated by the Platelet-Activating Factor Receptor. Mediators of Inflammation No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1001185
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bachi, André Luis Lacerda& dos Santos, Lívia Caires& Nonogaki, Suely& Jancar, Sonia& Jasiulionis, Miriam Galvonas. Apoptotic Cells Contribute to Melanoma Progression and This Effect is Partially Mediated by the Platelet-Activating Factor Receptor. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1001185
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1001185
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر