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Tissues Use Resident Dendritic Cells and Macrophages to Maintain Homeostasis and to Regain Homeostasis upon Tissue Injury: The Immunoregulatory Role of Changing Tissue Environments
المؤلفون المشاركون
Anders, Hans-Joachim
Lech, Maciej
Gröbmayr, Regina
Weidenbusch, Marc
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-02
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and macrophages.
A classification that sufficiently covers their phenotypic heterogeneity and plasticity during homeostasis and disease does not yet exist because cell culture-based phenotypes often do not match those found in vivo.
The plasticity of mononuclear phagocytes becomes obvious during dynamic or complex disease processes.
Different data interpretation also originates from different conceptual perspectives.
An immune-centric view assumes that a particular priming of phagocytes then causes a particular type of pathology in target tissues, conceptually similar to antigen-specific T-cell priming.
A tissue-centric view assumes that changing tissue microenvironments shape the phenotypes of their resident and infiltrating mononuclear phagocytes to fulfill the tissue's need to maintain or regain homeostasis.
Here we discuss the latter concept, for example, why different organs host different types of mononuclear phagocytes during homeostasis.
We further discuss how injuries alter tissue environments and how this primes mononuclear phagocytes to enforce this particular environment, for example, to support host defense and pathogen clearance, to support the resolution of inflammation, to support epithelial and mesenchymal healing, and to support the resolution of fibrosis to the smallest possible scar.
Thus, organ- and disease phase-specific microenvironments determine macrophage and dendritic cell heterogeneity in a temporal and spatial manner, which assures their support to maintain and regain homeostasis in whatever condition.
Mononuclear phagocytes contributions to tissue pathologies relate to their central roles in orchestrating all stages of host defense and wound healing, which often become maladaptive processes, especially in sterile and/or diffuse tissue injuries.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lech, Maciej& Gröbmayr, Regina& Weidenbusch, Marc& Anders, Hans-Joachim. 2012. Tissues Use Resident Dendritic Cells and Macrophages to Maintain Homeostasis and to Regain Homeostasis upon Tissue Injury: The Immunoregulatory Role of Changing Tissue Environments. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1001260
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lech, Maciej…[et al.]. Tissues Use Resident Dendritic Cells and Macrophages to Maintain Homeostasis and to Regain Homeostasis upon Tissue Injury: The Immunoregulatory Role of Changing Tissue Environments. Mediators of Inflammation No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1001260
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lech, Maciej& Gröbmayr, Regina& Weidenbusch, Marc& Anders, Hans-Joachim. Tissues Use Resident Dendritic Cells and Macrophages to Maintain Homeostasis and to Regain Homeostasis upon Tissue Injury: The Immunoregulatory Role of Changing Tissue Environments. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1001260
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1001260
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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