Mouse Brain PSA-NCAM Levels Are Altered by Graded-Controlled Cortical Impact Injury
المؤلفون المشاركون
Budinich, Craig S.
Chen, HuaZhen
Lowe, Dennell
Rosenberger, John G.
Bernstock, Joshua D.
McCabe, Joseph T.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-15
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Traumatic brain injury (TBI) is a worldwide endemic that results in unacceptably high morbidity and mortality.
Secondary injury processes following primary injury are composed of intricate interactions between assorted molecules that ultimately dictate the degree of longer-term neurological deficits.
One comparatively unexplored molecule that may contribute to exacerbation of injury or enhancement of recovery is the posttranslationally modified polysialic acid form of neural cell adhesion molecule, PSA-NCAM.
This molecule is a critical modulator of central nervous system plasticity and reorganization after injury.
In this study, we used controlled cortical impact (CCI) to produce moderate or severe TBI in the mouse.
Immunoblotting and immunohistochemical analysis were used to track the early (2, 24, and 48 hour) and late (1 and 3 week) time course and location of changes in the levels of PSA-NCAM after TBI.
Variable and heterogeneous short- and long-term increases or decreases in expression were found.
In general, alterations in PSA-NCAM levels were seen in the cerebral cortex immediately after injury, and these reductions persisted in brain regions distal to the primary injury site, especially after severe injury.
This information provides a starting point to dissect the role of PSA-NCAM in TBI-related pathology and recovery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Budinich, Craig S.& Chen, HuaZhen& Lowe, Dennell& Rosenberger, John G.& Bernstock, Joshua D.& McCabe, Joseph T.. 2012. Mouse Brain PSA-NCAM Levels Are Altered by Graded-Controlled Cortical Impact Injury. Neural Plasticity،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1002408
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Budinich, Craig S.…[et al.]. Mouse Brain PSA-NCAM Levels Are Altered by Graded-Controlled Cortical Impact Injury. Neural Plasticity No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1002408
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Budinich, Craig S.& Chen, HuaZhen& Lowe, Dennell& Rosenberger, John G.& Bernstock, Joshua D.& McCabe, Joseph T.. Mouse Brain PSA-NCAM Levels Are Altered by Graded-Controlled Cortical Impact Injury. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1002408
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1002408
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر