Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders
المؤلفون المشاركون
Jun, Heechul
Mohammed Qasim Hussaini, Syed
Rigby, Michael J.
Jang, Mi-Hyeon
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-31
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Adult neurogenesis, the process of generating new neurons from neural stem cells, plays significant roles in synaptic plasticity, memory, and mood regulation.
In the mammalian brain, it continues to occur well into adulthood in discrete regions, namely, the hippocampus and olfactory bulb.
During the past decade, significant progress has been made in understanding the mechanisms regulating adult hippocampal neurogenesis and its role in the etiology of mental disorders.
In addition, adult hippocampal neurogenesis is highly correlated with the remission of the antidepressant effect.
In this paper, we discuss three major psychiatric disorders, depression, schizophrenia, and drug addiction, in light of preclinical evidence used in establishing the neurobiological significance of adult neurogenesis.
We interpret the significance of these results and pose questions that remain unanswered.
Potential treatments which include electroconvulsive therapy, deep brain stimulation, chemical antidepressants, and exercise therapy are discussed.
While consensus lacks on specific mechanisms, we highlight evidence which indicates that these treatments may function via an increase in neural progenitor proliferation and changes to the hippocampal circuitry.
Establishing a significant role of adult neurogenesis in the pathogenicity of psychiatric disorders may hold the key to potential strategies toward effective treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jun, Heechul& Mohammed Qasim Hussaini, Syed& Rigby, Michael J.& Jang, Mi-Hyeon. 2012. Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders. Neural Plasticity،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-1002462
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jun, Heechul…[et al.]. Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders. Neural Plasticity No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-1002462
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jun, Heechul& Mohammed Qasim Hussaini, Syed& Rigby, Michael J.& Jang, Mi-Hyeon. Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-1002462
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1002462
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر