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Hippocampal Neurogenesis, Cognitive Deficits and Affective Disorder in Huntington's Disease
المؤلفون المشاركون
Hannan, Anthony J.
Ransome, Mark I.
Renoir, Thibault
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Huntington’s disease (HD) is a neurodegenerative disorder caused by a tandem repeat expansion encoding a polyglutamine tract in the huntingtin protein.
HD involves progressive psychiatric, cognitive, and motor symptoms, the selective pathogenesis of which remains to be mechanistically elucidated.
There are a range of different brain regions, including the cerebral cortex and striatum, known to be affected in HD, with evidence for hippocampal dysfunction accumulating in recent years.
In this review we will focus on hippocampal abnormalities, in particular, deficits of adult neurogenesis.
We will discuss potential molecular mechanisms mediating disrupted hippocampal neurogenesis, and how this deficit of cellular plasticity may in turn contribute to specific cognitive and affective symptoms that are prominent in HD.
The generation of transgenic animal models of HD has greatly facilitated our understanding of disease mechanisms at molecular, cellular, and systems levels.
Transgenic HD mice have been found to show progressive behavioral changes, including affective, cognitive, and motor abnormalities.
The discovery, in multiple transgenic lines of HD mice, that adult hippocampal neurogenesis and synaptic plasticity is disrupted, may help explain specific aspects of cognitive and affective dysfunction.
Furthermore, these mouse models have provided insight into potential molecular mediators of adult neurogenesis deficits, such as disrupted serotonergic and neurotrophin signaling.
Finally, a number of environmental and pharmacological interventions which are known to enhance adult hippocampal neurogenesis have been found to have beneficial affective and cognitive effects in mouse models, suggesting common molecular targets which may have therapeutic utility for HD and related diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ransome, Mark I.& Renoir, Thibault& Hannan, Anthony J.. 2012. Hippocampal Neurogenesis, Cognitive Deficits and Affective Disorder in Huntington's Disease. Neural Plasticity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002464
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ransome, Mark I.…[et al.]. Hippocampal Neurogenesis, Cognitive Deficits and Affective Disorder in Huntington's Disease. Neural Plasticity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1002464
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ransome, Mark I.& Renoir, Thibault& Hannan, Anthony J.. Hippocampal Neurogenesis, Cognitive Deficits and Affective Disorder in Huntington's Disease. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002464
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1002464
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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