17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease
المؤلفون المشاركون
Philippens, Ingrid
Reading, Christopher L.
Nicoletti, Ferdinando
Ahlem, Clarence N.
Auci, Dominick L.
Fagone, Paolo
Frincke, James M.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases.
HE3286 was evaluated for blood-brain barrier (BBB) permeability in mice, and efficacy in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) murine model of Parkinson’s disease (PD).
We found that HE3286 freely penetrated the BBB.
HE3286 treatment significantly improved motor function compared to vehicle in the rotarod test (mean 58.2 sec versus 90.9 sec, P<0.0001), and reduced inflammatory mediator gene expression in the brain (inducible nitric oxide synthase, 20%, P=0.002; tumor necrosis factor α, 40%, P=0.038, and interleukin-1β, 33%, P=0.02) measured by reverse-transcriptase polymerase chain reaction.
Brain tissue histopathology and immunohistochemistry showed that HE3286 treatment increased the numbers of tyrosine hydroxylase-positive cells by 17% compared to vehicle (P=0.003), and decreased the numbers of damaged neurons by 38% relative to vehicle (P=0.029).
L-3,4-dihydroxyphenylalanine (L-DOPA) efficacy was not enhanced by concurrent administration of HE3286.
HE3286 administration prior to MPTP did not enhance efficacy.
Our data suggest a potential role for HE3286 in PD treatment, and provides incentive for further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nicoletti, Ferdinando& Philippens, Ingrid& Fagone, Paolo& Ahlem, Clarence N.& Reading, Christopher L.& Frincke, James M.…[et al.]. 2012. 17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease. Parkinson’s Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002852
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nicoletti, Ferdinando…[et al.]. 17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease. Parkinson’s Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1002852
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nicoletti, Ferdinando& Philippens, Ingrid& Fagone, Paolo& Ahlem, Clarence N.& Reading, Christopher L.& Frincke, James M.…[et al.]. 17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease. Parkinson’s Disease. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002852
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1002852
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر