Magnolol Protects against MPTPMPP+-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson’s Disease
المؤلفون المشاركون
Mitsumoto, Yasuhide
Muroyama, Akiko
Kobayashi, Shota
Lv, Cheng
Fujita, Aya
Fukuyama, Yoshiyasu
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of this study is to investigate the role of magnolol in preventing 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP-) induced neurodegeneration in mice and 1-methyl-4-phenylpyridinium ion-(MPP+-) induced cytotoxicity to human neuroblastoma SH-SY5Y cells and to examine the possible mechanisms.
Magnolol (30 mg/kg) was orally administered to C57BL/6N mice once a day for 4 or 5 days either before or after MPTP treatment.
Western blot analysis revealed that MPTP injections substantially decreased protein levels of dopamine transporter (DAT) and tyrosine hydroxylase (TH) and increased glial fibrillary acidic protein (GFAP) levels in the striatum.
Both treatments with magnolol significantly attenuated MPTP-induced decrease in DAT and TH protein levels in the striatum.
However, these treatments did not affect MPTP-induced increase in GFAP levels.
Moreover, oral administration of magnolol almost completely prevented MPTP-induced lipid peroxidation in the striatum.
In human neuroblastoma SH-SY5Y cells, magnolol significantly attenuated MPP+-induced cytotoxicity and the production of reactive oxygen species.
These results suggest that magnolol has protective effects via an antioxidative mechanism in both in vivo and in vitro models of Parkinson’s disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muroyama, Akiko& Fujita, Aya& Lv, Cheng& Kobayashi, Shota& Fukuyama, Yoshiyasu& Mitsumoto, Yasuhide. 2012. Magnolol Protects against MPTPMPP+-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson’s Disease. Parkinson’s Disease،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1002854
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muroyama, Akiko…[et al.]. Magnolol Protects against MPTPMPP+-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson’s Disease. Parkinson’s Disease No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1002854
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muroyama, Akiko& Fujita, Aya& Lv, Cheng& Kobayashi, Shota& Fukuyama, Yoshiyasu& Mitsumoto, Yasuhide. Magnolol Protects against MPTPMPP+-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson’s Disease. Parkinson’s Disease. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1002854
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1002854
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر