Desmoid Fibromatosis in Pediatric Patients: Management Based on a Retrospective Analysis of 59 Patients and a Review of the Literature
المؤلفون المشاركون
Habrand, Jean-Louis
Helfre, Sylvie
Glorion, Christophe
Orbach, Daniel
Oudot, Caroline
Michon, Jean
Oberlin, Odile
Mary, Pierre
Minard-Colin, Véronique
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Only limited data are available concerning desmoid tumor in children.
Methods.
Fifty-nine children and adolescents with desmoid tumor treated in 2 French cancer centers with a very long followup were retrospectively reviewed.
Results.
Median age was 6 years (range, 0–15).
Tumors mainly involved the limbs (42%).
Five cases occurred in a context of genetic disorder.
Surgery was first-line treatment in 80% of cases.
Resection was microscopically complete in 3 patients (pts), with a microscopic residue in 19 pts and a macroscopic residue in 35 cases.
Various adjuvant therapies were used.
Overall response to all systemic therapies was 33%.
Thirty-eight patients developed one or more recurrences or progressions.
After a median followup of 8.5 years, 34 patients were alive in complete remission (CR), including 16 first CR.
Seven patients died, 6 from refractory disease and 1 from colorectal carcinoma in a genetic context.
Ten-year progression-free survival (PFS) and overall survival were 31% and 88%, respectively.
In univariate analysis, age less than 10 years and head-neck site were favorable prognostic factors for PFS.
Conclusions.
When surgery is required, surgical margins must be negative.
Low-dose chemotherapy can be proposed as adjuvant therapy.
Prospective trials must be developed to evaluate long-term response and side effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oudot, Caroline& Orbach, Daniel& Minard-Colin, Véronique& Michon, Jean& Mary, Pierre& Glorion, Christophe…[et al.]. 2012. Desmoid Fibromatosis in Pediatric Patients: Management Based on a Retrospective Analysis of 59 Patients and a Review of the Literature. Complexity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1002902
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oudot, Caroline…[et al.]. Desmoid Fibromatosis in Pediatric Patients: Management Based on a Retrospective Analysis of 59 Patients and a Review of the Literature. Complexity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1002902
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oudot, Caroline& Orbach, Daniel& Minard-Colin, Véronique& Michon, Jean& Mary, Pierre& Glorion, Christophe…[et al.]. Desmoid Fibromatosis in Pediatric Patients: Management Based on a Retrospective Analysis of 59 Patients and a Review of the Literature. Complexity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1002902
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1002902
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر