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Low-Grade Central Osteosarcoma: A Difficult Condition to Diagnose
المؤلفون المشاركون
Carter, Simon R.
James, S. L.
Malhas, A. M.
Sumathi, Vaiyapuri
Tillman, Roger M.
Jeys, L. M.
Grimer, Robert J.
Menna, C.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Low-grade central osteosarcoma (LGCO) is a rare variant of osteosarcoma which is difficult to diagnose.
If not treated appropriately, the tumour can recur with higher-grade disease.
We reviewed our experience of this condition to try and identify factors that could improve both diagnosis and outcome.
18 patients out of 1540 osteosarcoma cases (over 25 years) had LGCO (1.2%).
Only 11 patients (61%) were direct primary referrals.
Almost 40% (7 of 18) cases were referred after treatment elsewhere when the diagnosis had not been made initially and all presented with local recurrence.
Of the 11 who presented primarily, the first biopsy was diagnostic in only 6 (55%) cases.
Of the remaining cases, up to three separate biopsies were required before a definitive diagnosis was made.
Overall survivorship at 5 years was 90%.
17 patients were treated with limb salvage procedures, and one patient had an amputation.
The diagnosis of LGCO remains challenging due to the relatively nonspecific radiological and histological findings.
Since treatment of LGCO is so different to a benign lesion, accurate diagnosis is essential.
Any difficult or nondiagnostic biopsies of solitary bone lesions should be referred to specialist tumour units for a second opinion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Malhas, A. M.& Sumathi, Vaiyapuri& James, S. L.& Menna, C.& Carter, Simon R.& Tillman, Roger M.…[et al.]. 2012. Low-Grade Central Osteosarcoma: A Difficult Condition to Diagnose. Complexity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002927
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Malhas, A. M.…[et al.]. Low-Grade Central Osteosarcoma: A Difficult Condition to Diagnose. Complexity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1002927
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Malhas, A. M.& Sumathi, Vaiyapuri& James, S. L.& Menna, C.& Carter, Simon R.& Tillman, Roger M.…[et al.]. Low-Grade Central Osteosarcoma: A Difficult Condition to Diagnose. Complexity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002927
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1002927
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