Periostin as a Biomarker of the Amniotic Membrane

المؤلفون المشاركون

Chuva de Sousa Lopes, Susana M.
Umans, Lieve
Zwijsen, An
Dobreva, Mariya P.
Lhoest, Larissa
Pereira, Paulo N. G.

المصدر

Stem Cells International

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-07-01

دولة النشر

مصر

عدد الصفحات

10

الملخص EN

Tracing the precise developmental origin of amnion and amnion-derived stem cells is still challenging and depends chiefly on analyzing powerful genetic model amniotes like mouse.

Profound understanding of the fundamental differences in amnion development in both the disc-shaped primate and human embryo and the cup-shaped mouse embryo is pivotal in particular when sampling amniotic membrane from nonprimate species for isolating candidate amniotic stem cells.

The availability of molecular marker genes that are specifically expressed in the amniotic membrane and not in other extraembryonic membranes would be instrumental to validate unequivocally the starting material under investigation.

So far such amniotic markers have not been reported.

We postulated that bone morphogenetic protein (BMP) target genes are putative amniotic membrane markers mainly because deficiency in one of several components of the BMP signaling cascade in mice has been documented to result in defective development of the early amnion.

Comparative gene expression analysis of acknowledged target genes for BMP in different extraembryonic tissues, combined with in situ hybridization, identified Periostin (Postn) mRNA enrichment in amnion throughout gestation.

In addition, we identify and propose a combination of markers as transcriptional signature for the different extraembryonic tissues in mouse.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Dobreva, Mariya P.& Lhoest, Larissa& Pereira, Paulo N. G.& Umans, Lieve& Chuva de Sousa Lopes, Susana M.& Zwijsen, An. 2012. Periostin as a Biomarker of the Amniotic Membrane. Stem Cells International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1003139

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Dobreva, Mariya P.…[et al.]. Periostin as a Biomarker of the Amniotic Membrane. Stem Cells International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1003139

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Dobreva, Mariya P.& Lhoest, Larissa& Pereira, Paulo N. G.& Umans, Lieve& Chuva de Sousa Lopes, Susana M.& Zwijsen, An. Periostin as a Biomarker of the Amniotic Membrane. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1003139

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1003139