Dehydroepiandrosterone Stimulates Nerve Growth Factor and Brain Derived Neurotrophic Factor in Cortical Neurons
المؤلفون المشاركون
Shoae-Hassani, Alireza
Kheradmand, Danial
Rahmani, Anahita
Darbandi-Azar, Amir
Keyhanvar, Peyman
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Due to the increasing cases of neurodegenerative diseases in recent years, the eventual goal of nerve repair is very important.
One approach for achieving a neuronal cell induction is by regenerative pharmacology.
Nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) are neurotrophins that play roles in neuronal development, differentiation, and protection.
On the other hand, dehydroepiandrosterone (DHEA) is a neurosteroid which has multiple actions in the nervous system.
DHEA could be an important agent in regenerative pharmacology for neuronal differentiation during tissue regeneration.
In this study, we investigated the possible role of DHEA to modulate NGF and BDNF production.
The in vivo level of neurotrophins expression was demonstrated by ELISA in rat harvested brain cortex.
Also neurotrophins expression after DHEA treatment was revealed by the increased neurite extension, immunostaining, and BrdU labeling in rats.
Anti-NGF and anti-BDNF antibodies were used as suppressive agents on neurogenesis.
The results showed that NGF and BDNF are overproduced after DHEA treatment but there is not any overexpression for NT-3 and NT-4.
Also DHEA increased neurite extension and neural cell proliferation significantly.
Overall, DHEA might induce NGF and BDNF neurotrophins overproduction in cortical neurons which promotes neural cell protection, survival, and proliferation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rahmani, Anahita& Shoae-Hassani, Alireza& Keyhanvar, Peyman& Kheradmand, Danial& Darbandi-Azar, Amir. 2013. Dehydroepiandrosterone Stimulates Nerve Growth Factor and Brain Derived Neurotrophic Factor in Cortical Neurons. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003212
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rahmani, Anahita…[et al.]. Dehydroepiandrosterone Stimulates Nerve Growth Factor and Brain Derived Neurotrophic Factor in Cortical Neurons. Advances in Pharmacological and Pharmaceutical Sciences No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1003212
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rahmani, Anahita& Shoae-Hassani, Alireza& Keyhanvar, Peyman& Kheradmand, Danial& Darbandi-Azar, Amir. Dehydroepiandrosterone Stimulates Nerve Growth Factor and Brain Derived Neurotrophic Factor in Cortical Neurons. Advances in Pharmacological and Pharmaceutical Sciences. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1003212
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003212
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر