Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats
المؤلفون المشاركون
Sakthivel, Kunnathur Murugesan
Guruvayoorappan, Chandrasekaran
Kannan, Narayanan
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The potential biological functions of A.
nilotica have long been described in traditional system of medicine.
However, the protective effect of A.
nilotica on acetaminophen-induced hepatotoxicity is still unknown.
The present study attempted to investigate the protective effect of A.
nilotica against acetaminophen-induced hepatic damage in Wistar rats.
The biochemical liver functional tests Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP), total bilirubin, total protein, oxidative stress test (Lipid peroxidation), antioxidant parameter glutathione (GSH), and histopathological changes were examined.
Our results show that the pretreatment with A.
nilotica (250 mg/kg·bw) orally revealed attenuation of serum activities of ALT, AST, ALP, liver weight, and total bilirubin levels that were enhanced by administration of acetaminophen.
Further, pretreatment with extract elevated the total protein and GSH level and decreased the level of LPO.
Histopathological analysis confirmed the alleviation of liver damage and reduced lesions caused by acetaminophen.
The present study undoubtedly provides a proof that hepatoprotective action of A.
nilotica extract may rely on its effect on reducing the oxidative stress in acetaminophen-induced hepatic damage in rat model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kannan, Narayanan& Sakthivel, Kunnathur Murugesan& Guruvayoorappan, Chandrasekaran. 2013. Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003225
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kannan, Narayanan…[et al.]. Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003225
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kannan, Narayanan& Sakthivel, Kunnathur Murugesan& Guruvayoorappan, Chandrasekaran. Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003225
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003225
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر