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Cardiovascular and Renal Effects of Bromocriptine in Diabetic Patients with Stage 4 Chronic Kidney Disease
المؤلفون المشاركون
Mejía-Rodríguez, Oliva
Herrera-Abarca, Jorge E.
Ceballos-Reyes, Guillermo
Avila-Diaz, Marcela
Prado-Uribe, Carmen
Belio-Caro, Francisco
Salinas-González, Antonio
Vega-Gomez, Helios
Alvarez-Aguilar, Cleto
Lindholm, Bengt
García-López, Elvia
Paniagua, Ramón
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The objective of this study was to investigate the effect of bromocriptine (BEC) on left ventricular mass index (LVMI) and residual renal function (RRF) in chronic kidney disease (CKD) patients with type 2 diabetes (T2D).
Research Design and Methods.
A 6-month double-blind randomized controlled trial was conducted in 28 patients with T2D and stage 4 CKD with increased LVMI.
Fourteen patients received BEC (2.5 mg, initially 1 tablet with subsequent increase to three times a day) and 14 received a placebo (PBO; initially 1 tablet with subsequent increase to three times a day).
Cardiovascular changes were assessed by monitoring 24 h ambulatory blood pressure, two-dimensional-guided M-mode echocardiography, and N-terminal brain natriuretic peptide (NT-proBNP) plasma levels.
RRF was evaluated by creatinine clearance and cystatin-C plasma levels.
Results.
Both BEC and PBO groups decreased blood pressure—but the effect was more pronounced in the BEC group.
Average 24 h, diurnal and nocturnal blood pressures, and circadian profile showed improved values compared to the PBO group; LVMI decreased by 14% in BEC and increased by 8% in PBO group.
NT-proBNP decreased in BEC (0.54±0.15 to 0.32±0.17 pg/mL) and increased in PBO (0.37±0.15 to 0.64±0.17 pg/mL).
Creatinine clearance did not change in the BEC group and decreased in the PBO group.
Conclusions.
BEC resulted in a decrease on blood pressure and LVMI.
BEC also prevented the progression of CKD while maintaining the creatinine clearance unchanged.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mejía-Rodríguez, Oliva& Herrera-Abarca, Jorge E.& Ceballos-Reyes, Guillermo& Avila-Diaz, Marcela& Prado-Uribe, Carmen& Belio-Caro, Francisco…[et al.]. 2013. Cardiovascular and Renal Effects of Bromocriptine in Diabetic Patients with Stage 4 Chronic Kidney Disease. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003254
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mejía-Rodríguez, Oliva…[et al.]. Cardiovascular and Renal Effects of Bromocriptine in Diabetic Patients with Stage 4 Chronic Kidney Disease. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1003254
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mejía-Rodríguez, Oliva& Herrera-Abarca, Jorge E.& Ceballos-Reyes, Guillermo& Avila-Diaz, Marcela& Prado-Uribe, Carmen& Belio-Caro, Francisco…[et al.]. Cardiovascular and Renal Effects of Bromocriptine in Diabetic Patients with Stage 4 Chronic Kidney Disease. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003254
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003254
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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