![](/images/graphics-bg.png)
The Exposure of Breast Cancer Cells to Fulvestrant and Tamoxifen Modulates Cell Migration Differently
المؤلفون المشاركون
Lymperatou, Dionysia
Giannopoulou, Efstathia
Koutras, Angelos K.
Kalofonos, Haralabos P.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-02
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
There is no doubt that there are increased benefits of hormonal therapy to breast cancer patients; however, current evidence suggests that estrogen receptor (ER) blockage using antiestrogens is associated with a small induction of invasiveness in vitro.
The mechanism by which epithelial tumor cells escape from the primary tumor and colonize to a distant site is not entirely understood.
This study investigates the effect of two selective antagonists of the ER, Fulvestrant (Fulv) and Tamoxifen (Tam), on the invasive ability of breast cancer cells.
We found that 17β-estradiol (E2) demonstrated a protective role regarding cell migration and invasion.
Fulv did not alter this effect while Tam stimulated active cell migration according to an increase in Snail and a decrease in E-cadherin protein expression.
Furthermore, both tested agents increased expression of matrix metalloproteinases (MMPs) and enhanced invasive potential of breast cancer cells.
These changes were in line with focal adhesion kinase (FAK) rearrangement.
Our data indicate that the anti-estrogens counteracted the protective role of E2 concerning migration and invasion since their effect was not limited to antiproliferative events.
Although Fulv caused a less aggressive result compared to Tam, the benefits of hormonal therapy concerning invasion and metastasis yet remain to be investigated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lymperatou, Dionysia& Giannopoulou, Efstathia& Koutras, Angelos K.& Kalofonos, Haralabos P.. 2013. The Exposure of Breast Cancer Cells to Fulvestrant and Tamoxifen Modulates Cell Migration Differently. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1003430
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lymperatou, Dionysia…[et al.]. The Exposure of Breast Cancer Cells to Fulvestrant and Tamoxifen Modulates Cell Migration Differently. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1003430
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lymperatou, Dionysia& Giannopoulou, Efstathia& Koutras, Angelos K.& Kalofonos, Haralabos P.. The Exposure of Breast Cancer Cells to Fulvestrant and Tamoxifen Modulates Cell Migration Differently. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1003430
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003430
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)