Release of IL-1β Triggered by Milan Summer PM10: Molecular Pathways Involved in the Cytokine Release
المؤلفون المشاركون
Bengalli, Rossella
Molteni, Elisabetta
Longhin, Eleonora
Magne, Refsnes
Camatini, Marina
Gualtieri, Maurizio
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Particulate matter (PM) exposure is related to pulmonary and cardiovascular diseases, with increased inflammatory status.
The release of the proinflammatory interleukin- (IL-) 1β, is controlled by a dual pathway, the formation of inactive pro-IL-1β, through Toll-like receptors (TLRs) activation, and its cleavage by NLRP3 inflammasome.
THP-1-derived macrophages were exposed for 6 h to 2.5 μg/cm2 of Milan PM10, and the potential to promote IL-1β release by binding TLRs and activating NLRP3 has been examined.
Summer PM10, induced a marked IL-1β response in the absence of LPS priming (50-fold increase compared to unexposed cells), which was reduced by caspase-1 inhibition (91% of inhibition respect summer PM10-treated cells) and by TLR-2 and TLR-4 inhibitors (66% and 53% of inhibition, resp.).
Furthermore, summer PM10 increased the number of early endosomes, and oxidative stress inhibition nearly abolished PM10-induced IL-1β response (90% of inhibition).
These findings suggest that summer PM10 contains constituents both related to the activation of membrane TLRs and activation of the inflammasome NLPR3 and that TLRs activation is of pivotal importance for the magnitude of the response.
ROS formation seems important for PM10-induced IL-1β response, but further investigations are needed to elucidate the molecular pathway by which this effect is mediated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bengalli, Rossella& Molteni, Elisabetta& Longhin, Eleonora& Magne, Refsnes & Camatini, Marina& Gualtieri, Maurizio. 2013. Release of IL-1β Triggered by Milan Summer PM10: Molecular Pathways Involved in the Cytokine Release. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003538
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bengalli, Rossella…[et al.]. Release of IL-1β Triggered by Milan Summer PM10: Molecular Pathways Involved in the Cytokine Release. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003538
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bengalli, Rossella& Molteni, Elisabetta& Longhin, Eleonora& Magne, Refsnes & Camatini, Marina& Gualtieri, Maurizio. Release of IL-1β Triggered by Milan Summer PM10: Molecular Pathways Involved in the Cytokine Release. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003538
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003538
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر