Protective Effect of Thunbergia laurifolia (Linn.) on Lead Induced Acetylcholinesterase Dysfunction and Cognitive Impairment in Mice
المؤلفون المشاركون
Phyu, Moe Pwint
Tangpong, Jitbanjong
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Thunbergia laurifolia (linn., TL), a natural phenolic compound, has been reported to have many benefits and medicinal properties.
The current study ascertains the total phenolic content present in TL aqueous leaf extract and also examines the antioxidant ability of the extract in preserving acetylcholinesterase (AChE) activity of mice exposed to lead in vivo and in vitro model.
Mice were given lead acetate (Pb) in drinking water (1 g/L) together with TL 100 and 200 mg/kg/day.
The result showed that Pb induced AChE dysfunction in both in vitro and in vivo studies.
TL significantly prevented Pb induced neurotoxicity in a dose-dependent manner which was indicated by comparatively better performance of TL treated mice in Morris Water Maze Swimming Test and increased AChE activity in the tissue sample collected from the brains of these mice.
TL also exhibited the greatest amount of phenolic content, which has a significant positive correlation with its antioxidant capacity (P<0.05).
Taken together, these data suggested that the total phenolic compounds in TL could exhibit antioxidant and in part neuroprotective properties.
It may play a potential treatment strategy for Pb contamination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Phyu, Moe Pwint& Tangpong, Jitbanjong. 2013. Protective Effect of Thunbergia laurifolia (Linn.) on Lead Induced Acetylcholinesterase Dysfunction and Cognitive Impairment in Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003647
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Phyu, Moe Pwint& Tangpong, Jitbanjong. Protective Effect of Thunbergia laurifolia (Linn.) on Lead Induced Acetylcholinesterase Dysfunction and Cognitive Impairment in Mice. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1003647
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Phyu, Moe Pwint& Tangpong, Jitbanjong. Protective Effect of Thunbergia laurifolia (Linn.) on Lead Induced Acetylcholinesterase Dysfunction and Cognitive Impairment in Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1003647
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003647
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر