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Organic Anion Transporter 5 Renal Expression and Urinary Excretion in Rats with Vascular Calcification
المؤلفون المشاركون
Hazelhoff, María Herminia
Bulacio, Romina Paula
Torres, Adriana Mónica
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
It has been described renal damage in rats with vascular calcification.
The organic anion transporter 5 (Oat5) is only expressed in kidney, and its urinary excretion was proposed as potential early biomarker of renal injury.
The aim of this study was to evaluate the Oat5 renal expression and its urinary excretion in an experimental model of vascular calcification in comparison with traditional markers of renal injury.
Vascular calcification was obtained by the administration of an overdose of vitamin D3 (300,000 IU/kg, b.w., i.m.) to male Wistar rats.
Oat5 urinary abundance was evaluated by Western blotting.
Traditional markers of renal injury, such as creatinine and urea plasma levels, urinary protein levels, and urinary alkaline phosphatase (AP) activity, were determined using commercial kits.
Histology was assessed by hematoxylin/eosin staining.
Oat5 renal expression was evaluated by Western blotting and by immunohistochemistry.
An increased expression of Oat5 in renal homogenates, in apical membranes, and in its urinary excretion was observed in rats with vascular calcification.
The traditional parameters used to evaluate renal function were not modified, with the exception of histology.
It is possible to postulate the urinary excretion of Oat5 as a potential noninvasive biomarker of renal injury associated with vascular calcification.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hazelhoff, María Herminia& Bulacio, Romina Paula& Torres, Adriana Mónica. 2013. Organic Anion Transporter 5 Renal Expression and Urinary Excretion in Rats with Vascular Calcification. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003886
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hazelhoff, María Herminia…[et al.]. Organic Anion Transporter 5 Renal Expression and Urinary Excretion in Rats with Vascular Calcification. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1003886
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hazelhoff, María Herminia& Bulacio, Romina Paula& Torres, Adriana Mónica. Organic Anion Transporter 5 Renal Expression and Urinary Excretion in Rats with Vascular Calcification. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003886
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003886
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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