Depigmented Allergoids Reveal New Epitopes with Capacity to Induce IgG Blocking Antibodies
المؤلفون المشاركون
López-Matas, M. Angeles
Gallego, Mayte
Iraola, Víctor
Robinson, Douglas
Carnés, Jerónimo
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The synthesis of allergen-specific blocking IgGs that interact with IgE after allergen immunotherapy (SIT) has been related to clinical efficacy.
The objectives were to investigate the epitope specificity of IgG-antibodies induced by depigmented-polymerized (Dpg-Pol) allergoids and unmodified allergen extracts, and examine IgE-blocking activity of induced IgG-antibodies.
Methods.
Rabbits were immunized with native and Dpg-Pol extracts of birch pollen, and serum samples were obtained.
Recognition of linear IgG-epitopes of Bet v 1 and Bet v 2 and the capacity of these IgG-antibodies to block binding of human-IgE was determined.
Results.
Serum from rabbits immunized with native extracts recognised 11 linear epitopes from Bet v 1, while that from Dpg-Pol-immunized animals recognised 8.
For Bet v 2, 8 epitopes were recognized by IgG from native immunized animals, and 9 from Dpg-Pol immunized one.
Dpg-Pol and native immunized serum did not always recognise the same epitopes, but specific-IgG from both could block human-IgE binding sites for native extract.
Conclusions.
Depigmented-polymerized birch extract stimulates the synthesis of specific IgG-antibodies which recognize common but also novel epitopes compared with native extracts.
IgG-antibodies induced by Dpg-Pol effectively inhibit human-IgE binding to allergens which may be part of the mechanism of action of SIT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
López-Matas, M. Angeles& Gallego, Mayte& Iraola, Víctor& Robinson, Douglas& Carnés, Jerónimo. 2013. Depigmented Allergoids Reveal New Epitopes with Capacity to Induce IgG Blocking Antibodies. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003893
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
López-Matas, M. Angeles…[et al.]. Depigmented Allergoids Reveal New Epitopes with Capacity to Induce IgG Blocking Antibodies. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1003893
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
López-Matas, M. Angeles& Gallego, Mayte& Iraola, Víctor& Robinson, Douglas& Carnés, Jerónimo. Depigmented Allergoids Reveal New Epitopes with Capacity to Induce IgG Blocking Antibodies. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003893
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003893
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر