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In Vitro and In Vivo Investigation of the Potential of Amorphous Microporous Silica as a Protein Delivery Vehicle
المؤلفون المشاركون
Chaudhari, Amol
Vanmellaert, Lieve
Bauwens, Matthias
Vermaelen, Peter
Deroose, Christophe M.
Naert, Ignace
Cardoso, Marcio Vivan
Martens, Johan A.
Duyck, Joke
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Delivering growth factors (GFs) at bone/implant interface needs to be optimized to achieve faster osseointegration.
Amorphous microporous silica (AMS) has a potential to be used as a carrier and delivery platform for GFs.
In this work, adsorption (loading) and release (delivery) mechanism of a model protein, bovine serum albumin (BSA), from AMS was investigated in vitro as well as in vivo.
In general, strong BSA adsorption to AMS was observed.
The interaction was stronger at lower pH owing to favorable electrostatic interaction.
In vitro evaluation of BSA release revealed a peculiar release profile, involving a burst release followed by a 6 h period without appreciable BSA release and a further slower release later.
Experimental data supporting this observation are discussed.
Apart from understanding protein/biomaterial (BSA/AMS) interaction, determination of in vivo protein release is an essential aspect of the evaluation of a protein delivery system.
In this regard micropositron emission tomography (μ-PET) was used in an exploratory experiment to determine in vivo BSA release profile from AMS.
Results suggest stronger in vivo retention of BSA when adsorbed on AMS.
This study highlights the possible use of AMS as a controlled protein delivery platform which may facilitate osseointegration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chaudhari, Amol& Vanmellaert, Lieve& Bauwens, Matthias& Vermaelen, Peter& Deroose, Christophe M.& Naert, Ignace…[et al.]. 2013. In Vitro and In Vivo Investigation of the Potential of Amorphous Microporous Silica as a Protein Delivery Vehicle. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003956
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chaudhari, Amol…[et al.]. In Vitro and In Vivo Investigation of the Potential of Amorphous Microporous Silica as a Protein Delivery Vehicle. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1003956
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chaudhari, Amol& Vanmellaert, Lieve& Bauwens, Matthias& Vermaelen, Peter& Deroose, Christophe M.& Naert, Ignace…[et al.]. In Vitro and In Vivo Investigation of the Potential of Amorphous Microporous Silica as a Protein Delivery Vehicle. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003956
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003956
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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