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Cells with Stem Cell Characteristics in Somatic Compartments of the Ovary
المؤلفون المشاركون
Kossowska-Tomaszczuk, Katarzyna
De Geyter, Christian
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Antral follicular growth in the ovary is characterized by rapid expansion of granulosa cells accompanied by a rising complexity of their functionality.
Within two weeks the number of human granulosa cells increases from less than 500,000 to more than 50 millions cells per follicle and differentiates into groups of cells with a variety of specialized functions involved in steroidogenesis, nursing the oocyte, and forming a functional syncitium.
Both the rapid proliferation and different specialized functions of the granulosa cells can only be explained through the involvement of stem cells.
However, luteinizing granulosa cells were believed to be terminally differentiated cells.
Only recently, stem and progenitor cells with FSH-receptor activity were identified in populations of luteinizing granulosa cells obtained during oocyte collected for assisted reproduction.
In the presence of the leukaemia-inhibiting factor (LIF), it was possible to culture a subpopulation of the luteinizing granulosa cells over prolonged time periods.
Furthermore, when embedded in a matrix consisting of collagen type I, these cells continued to express the FSH receptor over prolonged time periods, developed globular formations that surrogated as follicle-like structures, providing a promising tool for reproductive biology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kossowska-Tomaszczuk, Katarzyna& De Geyter, Christian. 2012. Cells with Stem Cell Characteristics in Somatic Compartments of the Ovary. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003985
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kossowska-Tomaszczuk, Katarzyna& De Geyter, Christian. Cells with Stem Cell Characteristics in Somatic Compartments of the Ovary. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1003985
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kossowska-Tomaszczuk, Katarzyna& De Geyter, Christian. Cells with Stem Cell Characteristics in Somatic Compartments of the Ovary. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1003985
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003985
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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