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A Mouse Model of Interstitial Pneumonitis Induced by Murine Cytomegalovirus Infection after Allogeneic Skin Transplantation
المؤلفون المشاركون
Ni, Dequn
Yu, Haiyang
Zhang, Wei
Gan, Lin
Zhao, Jiqiang
Wang, Mingli
Chen, Jason
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We investigated the effect of murine cytomegalovirus (MCMV) on interstitial pneumonia in transplant recipients in an experimental skin allograft model.
Skin transplantation between C57BL/6J and BALB/c mice was performed in the presence or absence of cyclosporin A treatment.
Flow cytometry showed that the number of CD4+ and CD8+ cells and the level of IFN-γ decreased significantly in the groups treated with cyclosporin A.
We either mock-infected or infected the mice with MCMV by intranasal administration and monitored pathophysiological behavior and body weight.
The infected mice were sacrificed at different days postinfection for histology, immunohistochemistry, and molecular biological evaluations.
Interstitial pneumonitis was observed in positive control groups as well as in experimental group that received cyclosporin A, a skin transplant, and infected with the highest dose of virus (105 PFU).
Transmission electronic microscopy demonstrated the presence of herpes virus particles.
MCMV DNA and glycoprotein B were demonstrated in the epithelial cells of the lung tissue in those animals by in situ hybridization and immunohistochemistry, respectively.
Our data demonstrated the establishment of a mouse model of interstitial pneumonitis via MCMV infection after allogeneic skin transplantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ni, Dequn& Yu, Haiyang& Zhang, Wei& Gan, Lin& Zhao, Jiqiang& Wang, Mingli…[et al.]. 2013. A Mouse Model of Interstitial Pneumonitis Induced by Murine Cytomegalovirus Infection after Allogeneic Skin Transplantation. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004053
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ni, Dequn…[et al.]. A Mouse Model of Interstitial Pneumonitis Induced by Murine Cytomegalovirus Infection after Allogeneic Skin Transplantation. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1004053
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ni, Dequn& Yu, Haiyang& Zhang, Wei& Gan, Lin& Zhao, Jiqiang& Wang, Mingli…[et al.]. A Mouse Model of Interstitial Pneumonitis Induced by Murine Cytomegalovirus Infection after Allogeneic Skin Transplantation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1004053
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004053
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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