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Rapid Nongenomic Action of Aldosterone on Protein Expressions of Hsp90(α and β) and pc-Src in Rat Kidney
المؤلفون المشاركون
Eiam-Ong, Somchai
Eiam-Ong, Somchit
Sinphitukkul, Kittisak
Manotham, Krissanapong
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Previous in vitro studies indicated that aldosterone nongenomically phosphorylates epidermal growth factor receptor (EGFR) through activation of upstream signals, heat shock protein 90β (Hsp90β), and cytosolic (c)-Src kinase.
We demonstrated that aldosterone rapidly elevates EGFR phosphorylation in rat kidney.
There are no in vivo data regarding renal Hsp90(α and β) and phosphorylated (p)c-Src protein expressions.
The present study further investigates the expressions of these proteins.
Male Wistar rats were intraperitoneally injected with normal saline solution or aldosterone (Aldo: 150 μg/kg BW).
After 30 minutes, abundances and localizations of these proteins were determined.
Aldosterone enhanced renal Hsp90β protein abundance (P<0.001), but Hsp90α and pc-Src protein levels remained unaltered.
Expression of Hsp90(α and β) was induced prominently in the proximal convoluted tubules (PCTs).
Activation of Hsp90α was observed in vascular and outer medulla regions, whereas Hsp90β was induced in the cortex.
Immunoreactivity of pc-Src was elevated in PCT with obvious staining at the luminal membrane.
This in vivo study is the first to demonstrate that aldosterone nongenomically elevates Hsp90(α and β) protein expressions in rat kidney.
Aldosterone had no effect on pc-Src protein levels but modulated localization.
These results indicate that aldosterone regulates upstream mediators of EGFR transactivation in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eiam-Ong, Somchit& Sinphitukkul, Kittisak& Manotham, Krissanapong& Eiam-Ong, Somchai. 2013. Rapid Nongenomic Action of Aldosterone on Protein Expressions of Hsp90(α and β) and pc-Src in Rat Kidney. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004062
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eiam-Ong, Somchit…[et al.]. Rapid Nongenomic Action of Aldosterone on Protein Expressions of Hsp90(α and β) and pc-Src in Rat Kidney. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004062
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eiam-Ong, Somchit& Sinphitukkul, Kittisak& Manotham, Krissanapong& Eiam-Ong, Somchai. Rapid Nongenomic Action of Aldosterone on Protein Expressions of Hsp90(α and β) and pc-Src in Rat Kidney. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004062
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004062
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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