High Expression of H3K27me3 Is an Independent Predictor of Worse Outcome in Patients with Urothelial Carcinoma of Bladder Treated with Radical Cystectomy
المؤلفون المشاركون
Liu, Jianye
Li, Yonghong
Liao, Yiji
Mai, Shijuan
Zhang, Zhiling
Liu, Zhouwei
Jiang, Lijuan
Zeng, Yixin
Zhou, Fangjian
Xie, Dan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
It has been suggested that trimethylation of lysine 27 on histone H3 (H3K27me3) is a crucial epigenetic process in tumorigenesis.
However, the expression pattern of H3K27me3 and its clinicopathological/prognostic significance in urothelial carcinoma of bladder (UCB) are unclear.
In this study, upregulated expression of H3K27me3 protein was observed in the majority of UCBs by Western blotting.
High expression of H3K27me3 was examined by IHC in 59/126 (46.8%) of UCB tissues and in 18/72 (25.0%) of normal urothelial bladder epithelial tissues (P=0.002).
High expression of H3K27me3 was associated with multifocal tumors and lymph node metastases (P<0.05).
Patients with high expression of H3K27me3 had shorter cancer-specific survival (CSS) time than patients with low expression of H3K27me3 (P<0.001).
In different subsets of UCB patients, high expression of H3K27me3 was also a prognostic indicator in patients with grade 2 and grade 3, pT1, pT2, pT3, and pN− disease (P<0.05).
Importantly, expression of H3K27me3 was an independent predictor for CSS (P<0.001) of UCB patients treated with radical cystectomy (RC).
Our data suggests that high expression of H3K27me3 is an independent molecular marker for predicting poor prognosis of UCB patients treated with RC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Jianye& Li, Yonghong& Liao, Yiji& Mai, Shijuan& Zhang, Zhiling& Liu, Zhouwei…[et al.]. 2013. High Expression of H3K27me3 Is an Independent Predictor of Worse Outcome in Patients with Urothelial Carcinoma of Bladder Treated with Radical Cystectomy. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004177
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Jianye…[et al.]. High Expression of H3K27me3 Is an Independent Predictor of Worse Outcome in Patients with Urothelial Carcinoma of Bladder Treated with Radical Cystectomy. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004177
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Jianye& Li, Yonghong& Liao, Yiji& Mai, Shijuan& Zhang, Zhiling& Liu, Zhouwei…[et al.]. High Expression of H3K27me3 Is an Independent Predictor of Worse Outcome in Patients with Urothelial Carcinoma of Bladder Treated with Radical Cystectomy. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004177
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004177
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر