What Would Be the Most Appropriate αβ Ratio in the Setting of Stereotactic Body Radiation Therapy for Early Stage Non-Small Cell Lung Cancer
المؤلفون المشاركون
Chi, Alexander
Wen, Sijin
Liao, Zhongxing
Fowler, Jack
Xu, Jiahong
Nguyen, Nam P.
Welsh, James S.
Komaki, Ritsuko
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We hypothesize that the correlation between the radiation dose expressed as the biologically effective dose (BED) and the clinical endpoints will correlate better as the value of the α/β ratio is increased to >10 Gy, which theoretically minimizes the overestimation of the dose potency associated with the linear quadratic (LQ) formula in the setting of stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC).
A search was conducted in the PubMed electronic databases in August 2011.
In the studies analyzed, increasing the α/β ratio is associated with an increase in the strength of the correlation between isocenter BED and local control, especially in the studies with median followup of ≥24 months, for which Spearman’s correlation coefficients of 0.74–0.76 were achieved for α/β of 20 Gy, 30 Gy, and 50 Gy (P= 0.007–0.008).
A trend toward statistical significance was observed for the correlation of isocenter BED and the 2-year overall survival when an α/β of 20 Gy was used approached statistical significance (P=0.073).
Our results suggest that an α/β>10 Gy may be more appropriate for the prediction of dose response in the setting of lung SBRT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chi, Alexander& Wen, Sijin& Liao, Zhongxing& Fowler, Jack& Xu, Jiahong& Nguyen, Nam P.…[et al.]. 2013. What Would Be the Most Appropriate αβ Ratio in the Setting of Stereotactic Body Radiation Therapy for Early Stage Non-Small Cell Lung Cancer. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004186
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chi, Alexander…[et al.]. What Would Be the Most Appropriate αβ Ratio in the Setting of Stereotactic Body Radiation Therapy for Early Stage Non-Small Cell Lung Cancer. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004186
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chi, Alexander& Wen, Sijin& Liao, Zhongxing& Fowler, Jack& Xu, Jiahong& Nguyen, Nam P.…[et al.]. What Would Be the Most Appropriate αβ Ratio in the Setting of Stereotactic Body Radiation Therapy for Early Stage Non-Small Cell Lung Cancer. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004186
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004186
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر