Comparative Plasma Exposure and Lung Distribution of Two Human Use Commercial Azithromycin Formulations Assessed in Murine Model: A Preclinical Study
المؤلفون المشاركون
Rivulgo, Virginia
Sparo, Mónica
Ceci, Mónica
Fumuso, Elida
Confalonieri, Alejandra
Delpech, Gastón
Sánchez Bruni, Sergio F.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Azithromycin (AZM) therapeutic failure and relapses of patients treated with generic formulations have been observed in clinical practice.
The main goal of this research was to compare in a preclinical study the serum exposure and lung tissue concentration of two commercial formulations AZM-based in murine model.
The current study involved 264 healthy Balb-C.
Mice were divided into two groups (n=44): animals of Group A (reference formulation -R-) were orally treated with AZM suspension at 10 mg/kg of b.w.
Experimental animals of Group B (generic formulation -G-) received identical treatment than Group A with a generic formulation AZM-based.
The study was repeated twice as Phase II and III.
Serum and lung tissue samples were taken 24 h post treatment.
Validated microbiological assay was used to determine the serum pharmacokinetic and lung distribution of AZM.
After the pharmacokinetic analysis was observed, a similar serum exposure for both formulations of AZM assayed.
In contrast, statistical differences (P<0.001) were obtained after comparing the concentrations of both formulations in lung tissue, being the values obtained for AUC and Cmax (AZM-R-) +1586 and 122%, respectively, than those obtained for AZM-G- in lung.
These differences may indicate large differences on the distribution process of both formulations, which may explain the lack of efficacy/therapeutic failure observed on clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rivulgo, Virginia& Sparo, Mónica& Ceci, Mónica& Fumuso, Elida& Confalonieri, Alejandra& Delpech, Gastón…[et al.]. 2013. Comparative Plasma Exposure and Lung Distribution of Two Human Use Commercial Azithromycin Formulations Assessed in Murine Model: A Preclinical Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004195
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rivulgo, Virginia…[et al.]. Comparative Plasma Exposure and Lung Distribution of Two Human Use Commercial Azithromycin Formulations Assessed in Murine Model: A Preclinical Study. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1004195
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rivulgo, Virginia& Sparo, Mónica& Ceci, Mónica& Fumuso, Elida& Confalonieri, Alejandra& Delpech, Gastón…[et al.]. Comparative Plasma Exposure and Lung Distribution of Two Human Use Commercial Azithromycin Formulations Assessed in Murine Model: A Preclinical Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1004195
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004195
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر