Preparation, Physicochemical Characterization, and Cell Viability Evaluation of Long-Circulating and pH-Sensitive Liposomes Containing Ursolic Acid
المؤلفون المشاركون
Caldeira de Araújo Lopes, Sávia
Vinícius Melo Novais, Marcus
Salviano Teixeira, Cláudia
Honorato-Sampaio, Kinulpe
Tadeu Pereira, Márcio
Ferreira, Lucas Antônio Miranda
Braga, Fernão Castro
Cristina Oliveira, Mônica
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Cancer is one of the leading causes of death worldwide.
Although several drugs are used clinically, some tumors either do not respond or are resistant to the existing pharmacotherapy, thus justifying the search for new drugs.
Ursolic acid (UA) is a triterpene found in different plant species that has been shown to possess significant antitumor activity.
However, UA presents a low solubility in aqueous medium, which presents a barrier to its biological applications.
In this context, the use of liposomes presents a promising strategy to deliver UA and allow for its intravenous administration.
In this work, long-circulating and pH-sensitive liposomes containing UA (SpHL-UA) were developed, and their chemical and physicochemical properties were evaluated.
SpHL-UA presented adequate properties, including a mean diameter of 191.1 ± 6.4 nm, a zeta potential of 1.2 ± 1.4 mV, and a UA entrapment of 0.77 ± 0.01 mg/mL.
Moreover, this formulation showed a good stability after having been stored for 2 months at 4°C.
The viability studies on breast (MDA-MB-231) and prostate (LNCaP) cancer cell lines demonstrated that SpHL-UA treatment significantly inhibited cancer cell proliferation.
Therefore, the results of the present work suggest the applicability of SpHL-UA as a new and promising anticancer formulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Caldeira de Araújo Lopes, Sávia& Vinícius Melo Novais, Marcus& Salviano Teixeira, Cláudia& Honorato-Sampaio, Kinulpe& Tadeu Pereira, Márcio& Ferreira, Lucas Antônio Miranda…[et al.]. 2013. Preparation, Physicochemical Characterization, and Cell Viability Evaluation of Long-Circulating and pH-Sensitive Liposomes Containing Ursolic Acid. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Caldeira de Araújo Lopes, Sávia…[et al.]. Preparation, Physicochemical Characterization, and Cell Viability Evaluation of Long-Circulating and pH-Sensitive Liposomes Containing Ursolic Acid. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1004366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Caldeira de Araújo Lopes, Sávia& Vinícius Melo Novais, Marcus& Salviano Teixeira, Cláudia& Honorato-Sampaio, Kinulpe& Tadeu Pereira, Márcio& Ferreira, Lucas Antônio Miranda…[et al.]. Preparation, Physicochemical Characterization, and Cell Viability Evaluation of Long-Circulating and pH-Sensitive Liposomes Containing Ursolic Acid. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1004366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر