Carbon Nanofibers Have IgE Adjuvant Capacity but Are Less Potent Than Nanotubes in Promoting Allergic Airway Responses
المؤلفون المشاركون
Nygaard, Unni Cecilie
Samuelsen, Mari
Marioara, Calin Daniel
Løvik, Martinus
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
There is a growing concern for the possible health impact of nanoparticles.
The main objective of this study was to investigate the allergy-promoting capacity of four different carbon nanofiber (CNF) samples in an injection and an airway mouse model of allergy.
Secondly, the potency of the CNF was compared to the previously reported allergy-promoting capacity of carbon nanotubes (CNT) in the airway model.
Ultrafine carbon black particles (ufCBP) were used as a positive control.
Particles were given together with the allergen ovalbumin (OVA) either by subcutaneous injection into the footpad or intranasally to BALB/cA mice.
After allergen booster, OVA-specific IgE, IgG1, and IgG2a in serum were measured.
In the airway model, inflammation was determined as influx of inflammatory cells (eosinophils, neutrophils, lymphocytes, and macrophages) and by mediators (MCP-1 and TNF-α present in bronchoalveolar fluid (BALF)).
CNF and CNT both increased OVA-specific IgE levels in the two models, but in the airway model, the CNT gave a significantly stronger IgE response than the CNF.
Furthermore, the CNT and not the CNF promoted eosinophil lung inflammation.
Our data therefore suggest that nanotube-associated properties are particularly potent in promoting allergic responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nygaard, Unni Cecilie& Samuelsen, Mari& Marioara, Calin Daniel& Løvik, Martinus. 2013. Carbon Nanofibers Have IgE Adjuvant Capacity but Are Less Potent Than Nanotubes in Promoting Allergic Airway Responses. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004392
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nygaard, Unni Cecilie…[et al.]. Carbon Nanofibers Have IgE Adjuvant Capacity but Are Less Potent Than Nanotubes in Promoting Allergic Airway Responses. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1004392
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nygaard, Unni Cecilie& Samuelsen, Mari& Marioara, Calin Daniel& Løvik, Martinus. Carbon Nanofibers Have IgE Adjuvant Capacity but Are Less Potent Than Nanotubes in Promoting Allergic Airway Responses. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1004392
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004392
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر