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Mood and Memory Function in Ovariectomised Rats Exposed to Social Instability Stress
المؤلفون المشاركون
Wan Mohammad, Wan Mohd Zahiruddin
Al-Rahbi, Badriya
Zakaria, Rahimah
Othman, Zahiruddin
Hassan, Asma’
Muthuraju, Sangu
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This study aims to compare the effects of social instability stress on memory and anxiety- and depressive-like behaviour between sham-operated controls and ovariectomised (OVX) rats.
Forty adult female Sprague-Dawley rats (8 weeks old) were randomly divided into four groups, (n=10 per group).
These were non-stressed sham-operated control rats, stressed sham-operated control rats, non-stressed OVX rats, and stressed OVX rats.
The rats were subjected to social instability stress procedure for 15 days.
Novel object recognition, open field, and forced swim tests were conducted after the stress procedure.
Serum estradiol, ACTH and corticosterone levels were measured using commercially available ELISA kits.
Lower serum estradiol level and uterine weight with higher weight gain were observed in OVX rats compared to sham-operated controls.
Serum ACTH, and corticosterone levels were higher in stressed compared to non-stressed groups.
Memory deficit and anxiety- and depressive-like behaviour were significantly increased in stressed compared to non-stressed OVX rats but these changes were not seen in sham-operated controls.
These results suggest that the high circulating corticosterone acts synergistically with low circulating estradiol to exert negative effects on mood and memory function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-Rahbi, Badriya& Zakaria, Rahimah& Othman, Zahiruddin& Hassan, Asma’& Muthuraju, Sangu& Wan Mohammad, Wan Mohd Zahiruddin. 2013. Mood and Memory Function in Ovariectomised Rats Exposed to Social Instability Stress. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004449
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-Rahbi, Badriya…[et al.]. Mood and Memory Function in Ovariectomised Rats Exposed to Social Instability Stress. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1004449
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-Rahbi, Badriya& Zakaria, Rahimah& Othman, Zahiruddin& Hassan, Asma’& Muthuraju, Sangu& Wan Mohammad, Wan Mohd Zahiruddin. Mood and Memory Function in Ovariectomised Rats Exposed to Social Instability Stress. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1004449
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004449
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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