The Prognostic Significance of CD44V6, CDH11, and β-Catenin Expression in Patients with Osteosarcoma
المؤلفون المشاركون
Deng, Zhouming
Niu, Guangfeng
Cai, Lin
Wei, Renxiong
Zhao, Xiaolei
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This study aimed to examine the expression of and the relationship between CD44V6, CDH11, and β-catenin.
The expression of these cell adhesion molecules was detected in 90 osteosarcoma and 20 osteochondroma specimens using immunohistochemistry.
Associations between these parameters and clinicopathological data were also examined.
The expression rates of CD44V6, CDH11, and β-catenin were 25.0% (5/20), 70.0% (14/20), and 20.0% (4/20) in osteochondroma specimens, respectively.
Compared to osteochondromas, the proportions of expression of CD44V6 and β-catenin in osteosarcoma specimens increased to 65.6% (59/90) and 60.0% (54/90), respectively.
However, the expression rate of CDH11 in osteosarcomas was reduced to 40.0% (36/90).
The expression of these markers was significantly associated with metastasis and overall survival (P<0.05).
Survival analysis revealed that patients with increased expression of CD44V6 and β-catenin as well as decreased expression of CDH11 were correlated with a shorter survival time.
Multivariate analysis indicated that clinical stage, metastasis status, and the expression of CD44V6, CDH11, and β-catenin were found to be associated with overall survival.
Further, the expression of β-catenin and that of CD44V6 were positively correlated with each other.
Thus, our results indicated abnormal expression of CD44V6, CDH11, and β-catenin in osteosarcomas and osteochondromas, which may provide important indicators for further research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deng, Zhouming& Niu, Guangfeng& Cai, Lin& Wei, Renxiong& Zhao, Xiaolei. 2013. The Prognostic Significance of CD44V6, CDH11, and β-Catenin Expression in Patients with Osteosarcoma. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004453
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deng, Zhouming…[et al.]. The Prognostic Significance of CD44V6, CDH11, and β-Catenin Expression in Patients with Osteosarcoma. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004453
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deng, Zhouming& Niu, Guangfeng& Cai, Lin& Wei, Renxiong& Zhao, Xiaolei. The Prognostic Significance of CD44V6, CDH11, and β-Catenin Expression in Patients with Osteosarcoma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004453
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1004453
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر